Catalog Number: 4173
Chemical Name: (R)-(+)-α-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperinemethanol
Biological Activity
Potent and selective 5-HT2A receptor antagonist (Ki = 0.36 nM). Exhibits > 80-fold selectivity for 5-HT2A over other serotonergic receptor subtypes. Antipsychotic agent in vivo.
Technical Data
  • M.Wt:
    373.46
  • Formula:
    C22H28FNO3
  • Solubility:
    Soluble to 50 mM in 1eq. HCl and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    139290-65-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Preclinical characterization of the potential of the putative atypical antipsychotic MDL 100,907 as a potent 5-HT2A antagonist with a favorable CNS safety profile.
    Kehne et al.
    J.Pharmacol., 1996;277:968
  2. Characterization of the 5-HT2 receptor antagonist MDL 100907 as a putative atypical antipsychotic: behavioral, electrophysiological and neurochemical studies.
    Sorensen et al.
    J.Pharmacol.Exp.Ther., 1993;266:684
  3. The 5-hydroxytryptamine2A receptor antagonist R-(+)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl-4-piperidinemethanol (M100907) attenuates impulsivity after both drug-induced disruption (dizocilpine) and enhancement (antidepressant dr
    Ardayfio et al.
    J.Pharmacol.Exp.Ther., 2008;327:891
Citations:

The citations listed below are publications that use Tocris products. Selected citations for MDL 100907 include:

2 Citations: Showing 1 - 2
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  1. Increased serotonin transporter expression reduces fear and recruitment of parvalbumin interneurons of the amygdala.
    Authors: Bocchio Et al.
    Neuropsychopharmacology 2015;40:3015
  2. Essential role of brain-derived neurotrophic factor in the regulation of serotonin transmission in the basolateral amygdala.
    Authors: Daftary Et al.
    Neuroscience 2012;224:125

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