Catalog Number: 2864
Chemical Name: N,N-Dimethylimidodicarbonimidic diamide hydrochloride
Biological Activity
Antidiabetic agent; lowers plasma glucose levels and improves insulin sensitivity. Inhibits hepatic gluconeogenesis via activation of the LKB1/AMPK pathway. Displays antiproliferative effects in cancer cell lines. Activates the aPKC-CBP pathway in neural precursors to promote neurogenesis.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water and to 50 mM in DMSO
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth.

    Proc Natl Acad Sci U S A, 2013;110(3):972-7.
  2. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin.
    Shaw et al.
    Science, 2005;310:1642
  3. AMP-activated protein kinase in metabolic control and insulin signalling.
    Towler and Hardie
    Circ.Res., 2007;100:328
  4. Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation.
    Wang et al.
    Cell Stem Cell, 2012;11:23
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