Antidiabetic agent; lowers plasma glucose levels and improves insulin sensitivity. Inhibits hepatic gluconeogenesis via activation of the LKB1/AMPK pathway. Displays antiproliferative effects in cancer cell lines. Activates the aPKC-CBP pathway in neural precursors to promote neurogenesis.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Other Product-Specific Information:
Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth.
Proc Natl Acad Sci U S A, 2013;110(3):972-7.
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin.
Shaw et al.
AMP-activated protein kinase in metabolic control and insulin signalling.
Towler and Hardie
Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation.
Wang et al.
Cell Stem Cell, 2012;11:23
The citations listed below are publications that use Tocris products. Selected citations for Metformin hydrochloride include:
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