Metformin hydrochloride
Tocris Bioscience | Catalog # 2864
Key Product Details
Description
Product Description
Metformin hydrochloride is an antidiabetic agent; lowers plasma glucose levels and improves insulin sensitivity. Inhibits hepatic gluconeogenesis via activation of the LKB1/AMPK pathway. Displays antiproliferative effects in cancer cell lines via inhibition of mitochondrial complex I (MRC-1). Activates the aPKC-CBP pathway in neural precursors to promote neurogenesis. Activates autophagy. Identified by chemoinformatics as targeting human host proteins that interact with SARS-CoV-2. Metformin hydrochloride prevents brain atrophy, and slows the pace of aging across diverse tissues in animal studies.
Product Specifications for Metformin hydrochloride
Molecular Weight
Formula
Storage
Chemical Name
CAS Number
PubChem ID
InChI Key
SMILES
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 16.56 | 100 | |
| DMSO | 3.31 | 20 with gentle warming |
Preparing Stock Solutions for Metformin hydrochloride
The following data is based on the product molecular weight 165.62.
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 6.04 mL | 30.19 mL | 60.38 mL |
| 5 mM | 1.21 mL | 6.04 mL | 12.08 mL |
| 10 mM | 0.60 mL | 3.02 mL | 6.04 mL |
| 50 mM | 0.12 mL | 0.60 mL | 1.21 mL |
Calculators
Background References
References are publications that support the biological activity of the product. See our Citations tab to view 35 publications citing the usage of this product.
- Yang Metformin decelerates aging clock in male monkeys. Cell 2024 PMID: 39270656
- Wheaton MetfF inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis. Elife 2014 PMID: 24843020
- Gordon A SARS-CoV-2-human protein-protein interaction map reveals drug targets and potential drug-repurposing. Nature 2020 PMID: 32353859
- Galluzzi Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov. 2017 PMID: 28529316
- Wang MetF. activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation. Cell Stem Cell 2012 PMID: 22770240
- Hirsch MetF. inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth. Proc.Natl.Acad.Sci.USA 2013 PMID: 23277563
- Towler and Hardie AMP-activated protein kinase in metabolic control and Ins signalling. Circ.Res. 2007 PMID: 17307971
- Shaw The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of MetF.. Science 2005 PMID: 16308421
Product Documents for Metformin hydrochloride
Certificate of Analysis
To download a Certificate of Analysis, please enter a lot or batch number in the search box below.
Product Specific Notices for Metformin hydrochloride
For research use only
Related Research Areas
Citations for Metformin hydrochloride
Powered by Bioz
Customer Reviews for Metformin hydrochloride (3)
Have you used Metformin hydrochloride?
Submit a review and receive an Amazon gift card!
$25/€18/£15/$25CAN/¥2500 Yen for a review with an image
$10/€7/£6/$10CAN/¥1110 Yen for a review without an image
Submit a review
Customer Images
-
Species: MouseAssay Type: In VitroVerified Customer | Posted 11/11/2024Used on cell lines to test senolytic activity.
-
Species: HumanAssay Type: In VitroCell Line/Tissue: HPAFVerified Customer | Posted 03/21/20201 mM add to media for 24 hours
-
Species: MouseAssay Type: Ex VivoCell Line/Tissue: Brain sliceVerified Customer | Posted 01/30/2018Used in brain slices to activate AMPK, but no effect on cell dynamic was found. No positive control was used though, so unsure if lack of effect is due to drug...
There are no reviews that match your criteria.