Metformin hydrochloride

Catalog # Availability Size / Price Qty
2864/100
AMPK Activators Small Molecule
1 Image
Description: Activator of LKB1/AMPK; antidiabetic agent

Chemical Name: N,N-Dimethylimidodicarbonimidic diamide hydrochloride

Product Details
Citations (16)
Supplemental Products
Reviews (1)

Biological Activity

Antidiabetic agent; lowers plasma glucose levels and improves insulin sensitivity. Inhibits hepatic gluconeogenesis via activation of the LKB1/AMPK pathway. Displays antiproliferative effects in cancer cell lines. Activates the aPKC-CBP pathway in neural precursors to promote neurogenesis. Activates autophagy.

Deuterated analog also available.

Technical Data

M.Wt:
165.62
Formula:
C4H11N5.HCl
Solubility:
Soluble to 100 mM in water and to 20 mM in DMSO with gentle warming
Storage:
Store at RT
CAS No:
1115-70-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

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Citations for Metformin hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Metformin hydrochloride include:

16 Citations: Showing 1 - 10

  1. Repeat-associated non-AUG translation in C9orf72-ALS/FTD is driven by neuronal excitation and stress.
    Authors: Westergard Et al.
    EMBO Mol Med  2019;11
  2. Altered steady state and activity-dependent de novo protein expression in fragile X syndrome.
    Authors: Bowling Et al.
    Nat Commun  2019;10:1710
  3. AMP-Activated Protein Kinase Is Essential for the Maintenance of Energy Levels during Synaptic Activation.
    Authors: Marinangeli Et al.
    iScience  2018;9:1
  4. Expression of glycolytic enzymes in ovarian cancers and evaluation of the glycolytic pathway as a strategy for ovarian cancer treatment.
    Authors: Xintaropoulou Et al.
    BMC Cancer  2018;18:636
  5. Modification of tumour cell metabolism modulates sensitivity to Chk1 inhibitor-induced DNA damage.
    Authors: Massey
    Sci Rep  2017;7:40778
  6. Effects of MET and a Mammalian Target of Rapamycin (mTOR) ATP-Competitive Inhibitor on Targeted Metabolomics in Pancreatic Cancer Cell Line.
    Authors: Soliman Et al.
    Metabolomics (Los Angel)  2017;6
  7. Vitamin C alleviates aging defects in a stem cell model for Werner syndrome.
    Authors: Li Et al.
    Protein Cell  2016;7:478
  8. Development of telmis. in the therapy of spinal cord injury: pre-clinical study in rats.
    Authors: Lin Et al.
    Nat Commun  2015;9:4709
  9. Dipeptide species regulate p38MAPK-Smad3 signalling to maintain chronic myelogenous leukaemia stem cells.
    Authors: Naka Et al.
    BMC Cancer  2015;6:8039
  10. A comparative analysis of inhibitors of the glycolysis pathway in breast and ovarian cancer cell line models.
    Authors: Xintaropoulou Et al.
    Oncotarget  2015;6:25677

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Reviews for Metformin hydrochloride

Average Rating: 3 (Based on 1 Review)

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AMPK activation
By Anonymous on 01/30/2018
Species: Mouse

Used in brain slices to activate AMPK, but no effect on cell dynamic was found. No positive control was used though, so unsure if lack of effect is due to drug...


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