Metformin hydrochloride

  ( 11 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:2864
Chemical Name:N,N-Dimethylimidodicarbonimidic diamide hydrochloride
Product Details
Citations (11)
Supplemental Products
Reviews
Biological Activity
Antidiabetic agent; lowers plasma glucose levels and improves insulin sensitivity. Inhibits hepatic gluconeogenesis via activation of the LKB1/AMPK pathway. Displays antiproliferative effects in cancer cell lines. Activates the aPKC-CBP pathway in neural precursors to promote neurogenesis. Activates autophagy.

Deuterated analog also available.

Technical Data
  • M.Wt:
    165.62
  • Formula:
    C4H11N5.HCl
  • Solubility:
    Soluble to 100 mM in water and to 50 mM in DMSO
  • Storage:
    Store at RT
  • CAS No:
    1115-70-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Metformin hydrochloride include:

11 Citations: Showing 1 - 10
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  1. Modification of tumour cell metabolism modulates sensitivity to Chk1 inhibitor-induced DNA damage.
    Authors: Massey
    Sci Rep  2017;7:40778
  2. Vitamin C alleviates aging defects in a stem cell model for Werner syndrome.
    Authors: Li Et al.
    Protein Cell  2016;7:478
  3. Development of telmisartan in the therapy of spinal cord injury: pre-clinical study in rats.
    Authors: Lin Et al.
    Nat Commun  2015;9:4709
  4. Dipeptide species regulate p38MAPK-Smad3 signalling to maintain chronic myelogenous leukaemia stem cells.
    Authors: Naka Et al.
    BMC Cancer  2015;6:8039
  5. A comparative analysis of inhibitors of the glycolysis pathway in breast and ovarian cancer cell line models.
    Authors: Xintaropoulou Et al.
    Oncotarget  2015;6:25677
  6. Suppression of experimental arthritis through AMP-activated protein kinase activation and autophagy modulation.
    Authors: Yan Et al.
    J Rheum Dis Treat  2015;1:5
  7. Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway.
    Authors: Mo Et al.
    Nat Cell Biol  2015;17:500
  8. OxLDL induces endothelial dysfunction and death via TRAF3IP2: inhibition by HDL3 and AMPK activators.
    Authors: Valente Et al.
    Free Radic Biol Med  2014;70:117
  9. A cell-autonomous molecular cascade initiated by AMP-activated protein kinase represses steroidogenesis.
    Authors: Abdou Et al.
    Mol Cell Biol  2014;34:4257
  10. Activation of AMPK inhibits cervical cancer cell growth through AKT/FOXO3a/FOXM1 signaling cascade.
    Authors: Yung Et al.
    PLoS One  2013;13:327
  11. Comparative gene expression profiling of benign and malignant lesions reveals candidate therapeutic compounds for leiomyosarcoma.
    Authors: Edris Et al.
    Sarcoma  2012;2012:805614
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Average Rating: 3 (Based on 1 review)

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