Chemical Name: N,N-Dimethylimidodicarbonimidic diamide hydrochloride
Biological ActivityAntidiabetic agent; lowers plasma glucose levels and improves insulin sensitivity. Inhibits hepatic gluconeogenesis via activation of the LKB1/AMPK pathway. Displays antiproliferative effects in cancer cell lines. Activates the aPKC-CBP pathway in neural precursors to promote neurogenesis. Activates autophagy.
Deuterated analog also available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth.
Proc Natl Acad Sci U S A, 2013;110(3):972-7.
Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation.
Wang et al.
Cell Stem Cell, 2012;11:23
Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles.
Galluzzi et al.
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin.
Shaw et al.
AMP-activated protein kinase in metabolic control and insulin signalling.
Towler and Hardie
Citations for Metformin hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Metformin hydrochloride include:
11 Citations: Showing 1 - 10
Modification of tumour cell metabolism modulates sensitivity to Chk1 inhibitor-induced DNA damage.
Sci Rep 2017;7:40778
Vitamin C alleviates aging defects in a stem cell model for Werner syndrome.
Authors: Li Et al.
Protein Cell 2016;7:478
Development of telmisartan in the therapy of spinal cord injury: pre-clinical study in rats.
Authors: Lin Et al.
Nat Commun 2015;9:4709
Dipeptide species regulate p38MAPK-Smad3 signalling to maintain chronic myelogenous leukaemia stem cells.
Authors: Naka Et al.
BMC Cancer 2015;6:8039
A comparative analysis of inhibitors of the glycolysis pathway in breast and ovarian cancer cell line models.
Authors: Xintaropoulou Et al.
Suppression of experimental arthritis through AMP-activated protein kinase activation and autophagy modulation.
Authors: Yan Et al.
J Rheum Dis Treat 2015;1:5
Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway.
Authors: Mo Et al.
Nat Cell Biol 2015;17:500
OxLDL induces endothelial dysfunction and death via TRAF3IP2: inhibition by HDL3 and AMPK activators.
Authors: Valente Et al.
Free Radic Biol Med 2014;70:117
A cell-autonomous molecular cascade initiated by AMP-activated protein kinase represses steroidogenesis.
Authors: Abdou Et al.
Mol Cell Biol 2014;34:4257
Activation of AMPK inhibits cervical cancer cell growth through AKT/FOXO3a/FOXM1 signaling cascade.
Authors: Yung Et al.
PLoS One 2013;13:327
Comparative gene expression profiling of benign and malignant lesions reveals candidate therapeutic compounds for leiomyosarcoma.
Authors: Edris Et al.
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Used in brain slices to activate AMPK, but no effect on cell dynamic was found. No positive control was used though, so unsure if lack of effect is due to drug...