Catalog Number: 2864
Chemical Name: N,N-Dimethylimidodicarbonimidic diamide hydrochloride
Biological Activity
Antidiabetic agent; lowers plasma glucose levels and improves insulin sensitivity. Inhibits hepatic gluconeogenesis via activation of the LKB1/AMPK pathway. Displays antiproliferative effects in cancer cell lines. Activates the aPKC-CBP pathway in neural precursors to promote neurogenesis. Activates autophagy.

Deuterated analog also available.

Technical Data
  • M.Wt:
    165.62
  • Formula:
    C4H11N5.HCl
  • Solubility:
    Soluble to 100 mM in water and to 50 mM in DMSO
  • Storage:
    Store at RT
  • CAS No:
    1115-70-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth.

    Proc Natl Acad Sci U S A, 2013;110(3):972-7.
  2. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin.
    Shaw et al.
    Science, 2005;310:1642
  3. AMP-activated protein kinase in metabolic control and insulin signalling.
    Towler and Hardie
    Circ.Res., 2007;100:328
  4. Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation.
    Wang et al.
    Cell Stem Cell, 2012;11:23
  5. Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles.
    Galluzzi et al.
    Nat.Rev.Drug.Discov., 2017;
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Metformin hydrochloride include:

6 Citations: Showing 1 - 6
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  1. Modification of tumour cell metabolism modulates sensitivity to Chk1 inhibitor-induced DNA damage.
    Authors: Massey
    Sci Rep 2017;7:40778
  2. Development of telmisartan in the therapy of spinal cord injury: pre-clinical study in rats.
    Authors: Lin Et al.
    Nat Commun 2015;9:4709
  3. Dipeptide species regulate p38MAPK-Smad3 signalling to maintain chronic myelogenous leukaemia stem cells.
    Authors: Naka Et al.
    BMC Cancer 2015;6:8039
  4. Suppression of experimental arthritis through AMP-activated protein kinase activation and autophagy modulation.
    Authors: Yan Et al.
    J Rheum Dis Treat 2015;1:5
  5. Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway.
    Authors: Mo Et al.
    Nat Cell Biol 2015;17:500
  6. Activation of AMPK inhibits cervical cancer cell growth through AKT/FOXO3a/FOXM1 signaling cascade.
    Authors: Yung Et al.
    PLoS One 2013;13:327
Tocris Small Molecules
Description Application Cat# Citations Images  

Metformin - d6 hydrochloride

5533  
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