MIRA-1

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3362/10
3362/50
MIRA-1 | CAS No. 72835-26-8 | Additional p53-related Compounds
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Description: Restores mutant p53 activity; proapoptotic

Chemical Name: 1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2,5-dione

Product Details
Citations (1)
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Biological Activity

Restores wild-type conformation, function and DNA binding activity to mutant p53. Induces p53 transcriptional transactivation of p21, MDM2 and PUMA, and promotes tumor cell death by apoptosis in a mutant p53-dependent manner in vitro (IC50 = 10μM).

Technical Data

M.Wt:
183.16
Formula:
C8H9NO4
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Storage:
Store at +4°C
CAS No:
72835-26-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for MIRA-1

The citations listed below are publications that use Tocris products. Selected citations for MIRA-1 include:

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