Chemical Name: 1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2,5-dione
Biological ActivityMIRA-1 is a restores wild-type conformation, function and DNA binding activity to mutant p53. Induces p53 transcriptional transactivation of p21, MDM2 and PUMA, and promotes tumor cell death by apoptosis in a mutant p53-dependent manner in vitro (IC50 = 10μM).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs.
Bykov et al.
Strategies for therapeutic targeting of the p53 pathway in cancer.
Cell Death Differ., 2006;13:921
p53 in breast cancer: mutation and countermeasures.
Kumar et al.
Citation for MIRA-1
The citations listed below are publications that use Tocris products. Selected citations for MIRA-1 include:
1 Citation: Showing 1 - 1
Small molecule MIRA-1 induces in vitro and in vivo anti-myeloma activity and synergizes with current anti-myeloma agents.
Authors: Saha Et al.
Br J Cancer 2014;110:2224
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