Restores wild-type conformation, function and DNA binding activity to mutant p53. Induces p53 transcriptional transactivation of p21, MDM2 and PUMA, and promotes tumor cell death by apoptosis in a mutant p53-dependent manner in vitro
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Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs.
Bykov et al.
Strategies for therapeutic targeting of the p53 pathway in cancer.
Cell Death Differ., 2006;13:921
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