Biological Activity Restores wild-type conformation, function and DNA binding activity to mutant p53. Induces p53 transcriptional transactivation of p21, MDM2 and PUMA, and promotes tumor cell death by apoptosis in a mutant p53-dependent manner in vitro (IC50 = 10μM).
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Store at +4°C
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All Tocris products are intended for laboratory research use only.
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