MIRA-1

Key Product Details

Product Description

MIRA-1 is a restores wild-type conformation, function and DNA binding activity to mutant p53. Induces p53 transcriptional transactivation of p21, MDM2 and PUMA, and promotes tumor cell death by apoptosis in a mutant p53-dependent manner in vitro (IC₅₀ = 10μM).

Product Specifications for MIRA-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for MIRA-1

The following data is based on the product molecular weight 183.16.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.46 mL	27.30 mL	54.60 mL
5 mM	1.09 mL	5.46 mL	10.92 mL
10 mM	0.55 mL	2.73 mL	5.46 mL
50 mM	0.11 mL	0.55 mL	1.09 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Wiman Strategies for therapeutic targeting of the p53 pathway in cancer. Cell Death Differ. 2006 PMID: 16557267
• Kumar p53 in breast cancer: mutation and countermeasures. Front.Biosci. 2007 PMID: 17485365
• Bykov Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs. J.Biol.Chem. 2005 PMID: 15998635

Product Documents for MIRA-1