Catalog Number: 3362
Chemical Name: 1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2,5-dione
Biological Activity
Restores wild-type conformation, function and DNA binding activity to mutant p53. Induces p53 transcriptional transactivation of p21, MDM2 and PUMA, and promotes tumor cell death by apoptosis in a mutant p53-dependent manner in vitro (IC50 = 10μM).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs.
    Bykov et al.
    J.Biol.Chem., 2005;280:30384
  2. Strategies for therapeutic targeting of the p53 pathway in cancer.
    Cell Death Differ., 2006;13:921
  3. p53 in breast cancer: mutation and countermeasures.
    Kumar et al.
    Front.Biosci., 2007;12:4168
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