) leukotriene receptor inverse agonist (EC50
= 1.3 nM). Antagonizes LTD4
-induced contractions of guinea pig trachea and ileum (pA2
values are 9.4 and 10.5 respectively). Also inhibitor of multidrug resistance protein-1 (MRP1) mediated transport; in vitro
augments the effects of cytotoxic agents on malignant cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Interleukin-6 production by activated human monocytic cells is enhanced by MK-571, a specific inhibitor of the multi-drug resistance protein-1.
Vellenga et al.
Inverse agonist activity of selected ligands of the cysteinyl-leukotriene receptor 1.
Dupre et al.
Involvement of LTD4 in allergic pulmonary inflammation in mice: modulation by cysLT1 antagonist MK-571.
Blain and Sirois
Prost.Leuko.Essent.Fatty Acids, 2000;62:361
The citations listed below are publications that use Tocris products. Selected citations for MK 571 include:
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