Chemical Name: 3-[[[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl][[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]propanoic acid
Biological ActivityMK 571 is a potent CysLT1 (LTD4) leukotriene receptor inverse agonist (EC50 = 1.3 nM). Antagonizes LTD4-induced contractions of guinea pig trachea and ileum (pA2 values are 9.4 and 10.5 respectively). Also inhibitor of multidrug resistance protein-1 (MRP1) mediated transport; in vitro augments the effects of cytotoxic agents on malignant cells.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Interleukin-6 production by activated human monocytic cells is enhanced by MK-571, a specific inhibitor of the multi-drug resistance protein-1.
Vellenga et al.
Inverse agonist activity of selected ligands of the cysteinyl-leukotriene receptor 1.
Dupre et al.
Involvement of LTD4 in allergic pulmonary inflammation in mice: modulation by cysLT1 antagonist MK-571.
Blain and Sirois
Prost.Leuko.Essent.Fatty Acids, 2000;62:361
Citations for MK 571
The citations listed below are publications that use Tocris products. Selected citations for MK 571 include:
5 Citations: Showing 1 - 5
Phosphorylation-dependent modulation of CFTR macromolecular signalling complex activity by cigarette smoke condensate in airway epithelia.
Authors: Schnúr Et al.
Sci Rep 2019;9:12706
Pranlukast is a novel small molecule activator of the two-pore domain potassium channel TREK2.
Authors: Wright Et al.
Biochem Biophys Res Commun 2019;520:35
Raltegravir permeability across blood-tissue barriers and the potential role of drug efflux transporters.
Authors: Hoque Et al.
Biochem Pharmacol 2015;59:2572
A primary fish gill cell culture model to assess pharmaceutical uptake and efflux: evidence for passive and facilitated transport.
Authors: Stott Et al.
Antimicrob Agents Chemother 2015;159:127
Characterisation of the roles of ABCB1, ABCC1, ABCC2 and ABCG2 in the transport and pharmacokinetics of actinomycin D in vitro and in vivo.
Authors: Hill Et al.
Am J Physiol Heart Circ Physiol 2013;85:29
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