MK 571

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2338/10
MK 571 | CAS No. 115104-28-4 | Leukotriene and Related Receptor Inverse Agonists
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Description: Potent CysLT1 (LTD4) inverse agonist. Also MRP1 inhibitor
Alternative Names: L-660711

Chemical Name: 3-[[[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl][[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]propanoic acid

Product Details
Citations (5)
Supplemental Products
Reviews

Biological Activity

Potent CysLT1 (LTD4) leukotriene receptor inverse agonist (EC50 = 1.3 nM). Antagonizes LTD4-induced contractions of guinea pig trachea and ileum (pA2 values are 9.4 and 10.5 respectively). Also inhibitor of multidrug resistance protein-1 (MRP1) mediated transport; in vitro augments the effects of cytotoxic agents on malignant cells.

Technical Data

M.Wt:
515.09
Formula:
C26H27ClN2O3S2
Solubility:
Soluble to 100 mM in DMSO
Storage:
Store at -20°C
CAS No:
115104-28-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Interleukin-6 production by activated human monocytic cells is enhanced by MK-571, a specific inhibitor of the multi-drug resistance protein-1.
    Vellenga et al.
    Br.J.Pharmacol., 1999;127:441
  2. Inverse agonist activity of selected ligands of the cysteinyl-leukotriene receptor 1.
    Dupre et al.
    J.Pharmacol.Exp.Ther., 2004;309:102
  3. Involvement of LTD4 in allergic pulmonary inflammation in mice: modulation by cysLT1 antagonist MK-571.
    Blain and Sirois
    Prost.Leuko.Essent.Fatty Acids, 2000;62:361

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Citations for MK 571

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