Catalog Number: 2338
Alternate Names: L-660711
Chemical Name: 3-[[[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl][[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]propanoic acid
Biological Activity
Potent CysLT1 (LTD4) leukotriene receptor inverse agonist (EC50 = 1.3 nM). Antagonizes LTD4-induced contractions of guinea pig trachea and ileum (pA2 values are 9.4 and 10.5 respectively). Also inhibitor of multidrug resistance protein-1 (MRP1) mediated transport; in vitro augments the effects of cytotoxic agents on malignant cells.
Technical Data
  • M.Wt:
    515.09
  • Formula:
    C26H27ClN2O3S2
  • Solubility:
    Soluble to 100 mM in DMSO
  • Storage:
    Store at -20°C
  • CAS No:
    115104-28-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Interleukin-6 production by activated human monocytic cells is enhanced by MK-571, a specific inhibitor of the multi-drug resistance protein-1.
    Vellenga et al.
    Br.J.Pharmacol., 1999;127:441
  2. Inverse agonist activity of selected ligands of the cysteinyl-leukotriene receptor 1.
    Dupre et al.
    J.Pharmacol.Exp.Ther., 2004;309:102
  3. Involvement of LTD4 in allergic pulmonary inflammation in mice: modulation by cysLT1 antagonist MK-571.
    Blain and Sirois
    Prost.Leuko.Essent.Fatty Acids, 2000;62:361
Citations:

The citations listed below are publications that use Tocris products. Selected citations for MK 571 include:

3 Citations: Showing 1 - 3
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  1. Raltegravir permeability across blood-tissue barriers and the potential role of drug efflux transporters.
    Authors: Hoque Et al.
    Biochem Pharmacol 2015;59:2572
  2. A primary fish gill cell culture model to assess pharmaceutical uptake and efflux: evidence for passive and facilitated transport.
    Authors: Stott Et al.
    Antimicrob Agents Chemother 2015;159:127
  3. Characterisation of the roles of ABCB1, ABCC1, ABCC2 and ABCG2 in the transport and pharmacokinetics of actinomycin D in vitro and in vivo.
    Authors: Hill Et al.
    Am J Physiol Heart Circ Physiol 2013;85:29

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