MK 571

Tocris Bioscience | Catalog # 2338

Potent CysLT1 (LTD4) inverse agonist. Also MRP1 inhibitor
Tocris Bioscience

Key Product Details

Description

Potent CysLT1 (LTD4) inverse agonist. Also MRP1 inhibitor

Alternative Names

L-660711
View all Leukotriene and Related Receptor Inverse Agonists »

Product Description

MK 571 is a potent CysLT1 (LTD4) leukotriene receptor inverse agonist (EC50 = 1.3 nM). Antagonizes LTD4-induced contractions of guinea pig trachea and ileum (pA2 values are 9.4 and 10.5 respectively). Also inhibitor of multidrug resistance protein-1 (MRP1) mediated transport; in vitro augments the effects of cytotoxic agents on malignant cells.

Product Specifications for MK 571

Molecular Weight

515.09

Formula

C26H27ClN2O3S2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

3-[[[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl][[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]propanoic acid

CAS Number

115104-28-4

PubChem ID

5281888

InChI Key

AXUZQJFHDNNPFG-UXBLZVDNSA-N

SMILES

ClC1=CC=C(C=CC(/C=C/C3=CC(C(SCCC(O)=O)SCCC(N(C)C)=O)=CC=C3)=N2)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 51.51 100

Preparing Stock Solutions for MK 571

The following data is based on the product molecular weight 515.09.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.94 mL 9.71 mL 19.41 mL
5 mM 0.39 mL 1.94 mL 3.88 mL
10 mM 0.19 mL 0.97 mL 1.94 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 35 publications citing the usage of this product.

Product Documents for MK 571

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for MK 571

For research use only

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