ML 120B dihydrochloride

   
Product Datasheet
Catalog Number:4899
Chemical Name:N-(6-Chloro-7-methoxy-9H-pyrido[3,4-b]indol-8-yl)-2-methyl-3-pyridinecarboxamide dihydrochloride
Product Details
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Biological Activity
Novel, ATP-competitive IKK2-selective inhibitor (IC50 = 60 nM at 50 μM ATP). Exhibits no inhibition at IKK1 (EC50 >100 μM), IKKε (EC50 >100 μM) or a panel of 28 other kinases (EC50 >50 μM). Exhibits antitumor activity in lymphoma-bearing SCID mice. Demonstrates synergistic cytotoxic effects with vincristine (Cat. No. 1257).
Technical Data
  • M.Wt:
    439.72
  • Formula:
    C19H15ClN4O2.2HCl
  • Solubility:
    Soluble to 20 mM in DMSO and to 5 mM in water with gentle warming
  • Purity:
    >98
  • Storage:
    Store at +4°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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