ML 120B dihydrochloride

Catalog # Availability Size / Price Qty
4899/10
4899/50
ML 120B dihydrochloride | CAS No. 1782573-78-7 | IkB Kinase Inhibitors
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Description: Novel IKK2-selective inhibitor

Chemical Name: N-(6-Chloro-7-methoxy-9H-pyrido[3,4-b]indol-8-yl)-2-methyl-3-pyridinecarboxamide dihydrochloride

Purity: ≥98%

Product Details
Reviews (1)

Biological Activity

Novel, ATP-competitive IKK2-selective inhibitor (IC50 = 60 nM at 50 μM ATP). Exhibits no inhibition at IKK1 (EC50 >100 μM), IKKε (EC50 >100 μM) or a panel of 28 other kinases (EC50 >50 μM). Exhibits antitumor activity in lymphoma-bearing SCID mice. Demonstrates synergistic cytotoxic effects with vincristine (Cat. No. 1257).

Technical Data

M.Wt:
439.72
Formula:
C19H15ClN4O2.2HCl
Solubility:
Soluble to 20 mM in DMSO and to 5 mM in water with gentle warming
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1782573-78-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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ML 120B inhibits LPS-induced TNFa expression
By Anonymous on 12/11/2018
Species: Mouse

RAW macrophages were incubated with 1 μM ML 120B for 30 min prior to addition of 200 ng/ml LPS for 8 h to follow TNFa mRNA expression. LPS elevated TNFa mRNA levels that was significantly inhibited by pretreatment of cells with ML 120B.


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