ML 120B dihydrochloride

Tocris Bioscience | Catalog # 4899

Novel IKK2-selective inhibitor
Tocris Bioscience

Key Product Details

Description

Novel IKK2-selective inhibitor
View all IkB Kinase Inhibitors »

Product Description

ML 120B dihydrochloride is a novel, ATP-competitive IKK2-selective inhibitor (IC50 = 60 nM at 50 μM ATP). Exhibits no inhibition at IKK1 (EC50 >100 μM), IKKε (EC50 >100 μM) or a panel of 28 other kinases (EC50 >50 μM). Exhibits antitumor activity in lymphoma-bearing SCID mice. Demonstrates synergistic cytotoxic effects with vincristine (Cat. No. 1257).

Product Specifications for ML 120B dihydrochloride

Molecular Weight

439.72

Formula

C19H15ClN4O2.2HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-(6-Chloro-7-methoxy-9H-pyrido[3,4-b]indol-8-yl)-2-methyl-3-pyridinecarboxamide dihydrochloride

CAS Number

1782573-78-7

PubChem ID

90488985

InChI Key

AWKOVWFBTRXQLW-UHFFFAOYSA-N

SMILES

ClC1=C(OC)C(NC(C4=CC=CN=C4C)=O)=C2C(C(C=CN=C3)=C3N2)=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 2.2 5 with gentle warming
DMSO 8.79 20

Preparing Stock Solutions for ML 120B dihydrochloride

The following data is based on the product molecular weight 439.72.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 11.37 mL 56.85 mL 113.71 mL
1 mM 2.27 mL 11.37 mL 22.74 mL
2 mM 1.14 mL 5.69 mL 11.37 mL
10 mM 0.23 mL 1.14 mL 2.27 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

Product Documents for ML 120B dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for ML 120B dihydrochloride

For research use only

Citations for ML 120B dihydrochloride

Customer Reviews for ML 120B dihydrochloride (1)

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  • ML 120B inhibits LPS-induced TNFa expression
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: Macrophages
    Verified Customer | Posted 12/11/2018
    RAW macrophages were incubated with 1 μM ML 120B for 30 min prior to addition of 200 ng/ml LPS for 8 h to follow TNFa mRNA expression. LPS elevated TNFa mRNA levels that was significantly inhibited by pretreatment of cells with ML 120B.
    ML 120B dihydrochloride 4899

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