Chemical Name: 22-Oxovincaleukoblastine
Biological ActivityVincristine sulfate is a anticancer agent; microtubule disrupter. Induces apoptosis in human lymphoma cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitro.
Jordan et al.
Cancer Res., 1985;45:2741
Apoptosis induced by microtubule disrupting drugs in cultured human lymphoma cells. Inhibitory effects of phorbol ester and zinc sulphate.
Takano et al.
The effect of antimicrotubule agents on signal transduction pathways of apoptosis.
Wang et al.
Cancer Chemother.Pharmacol., 1999;44:355
Citations for Vincristine sulfate
The citations listed below are publications that use Tocris products. Selected citations for Vincristine sulfate include:
9 Citations: Showing 1 - 9
Epigenetic silencing of tumor suppressor Par-4 promotes chemoresistance in recurrent breast cancer.
Authors: Mabe Et al.
J Clin Invest 2018;128:4413
The BTK Inhibitor, Ibrutinib (PCI-32765) Overcomes PacT. Resistance in ABCB1 and ABCC10 Overexpressing Cells and Tumors.
Mol Cancer Ther 2017;16(6):1021
Adenosine A3 receptor elicits chemoresistance mediated by multiple resistance-associated protein-1 in human glioblastoma stem-like cells.
Authors: Torres Et al.
MicroRNA-138 promotes acquired alkylator resistance in glioblastoma by targeting the Bcl-2-interacting mediator BIM.
Authors: Stojcheva Et al.
Temporally sequenced anticancer drugs overcome adaptive resistance by targeting a vulnerable chemotherapy-induced phenotypic transition.
Authors: Goldman Et al.
Nat Commun 2015;6:6139
The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated PacT. resistance: a preclinical and pharmacokinetic study.
Authors: Kathawala Et al.
Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin Lymphomas.
Authors: Knutson Et al.
PLoS One 2014;9:e111840
Masitinib antagonizes ATP-binding cassette subfamily C member 10-mediated PacT. resistance: a preclinical study.
Authors: Kathawala Et al.
Mol Cancer Ther 2014;13:714
Synergistic effects of oncolytic reovirus and doce. chemotherapy in prostate cancer.
Authors: Heinemann Et al.
Sci Rep 2011;11:221
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