Catalog Number: 1257
Chemical Name: 22-Oxovincaleukoblastine
Biological Activity
Anticancer agent; microtubule disrupter. Induces apoptosis in human lymphoma cells.
Technical Data
  • M.Wt:
    923.04
  • Formula:
    C46H56N4O10.H2SO4
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >96%
  • Storage:
    Store at -20°C
  • CAS No:
    2068-78-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitro.
    Jordan et al.
    Cancer Res., 1985;45:2741
  2. The effect of antimicrotubule agents on signal transduction pathways of apoptosis.
    Wang et al.
    Cancer Chemother.Pharmacol., 1999;44:355
  3. Apoptosis induced by microtubule disrupting drugs in cultured human lymphoma cells. Inhibitory effects of phorbol ester and zinc sulphate.
    Takano et al.
    Pathol.Res.Pract., 1993;189:197
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Vincristine sulfate include:

4 Citations: Showing 1 - 4
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  1. The BTK Inhibitor, Ibrutinib (PCI-32765) Overcomes Paclitaxel Resistance in ABCB1 and ABCC10 Overexpressing Cells and Tumors.
    Authors: Zhang
    Mol Cancer Ther 2017;16(6):1021
  2. Temporally sequenced anticancer drugs overcome adaptive resistance by targeting a vulnerable chemotherapy-induced phenotypic transition.
    Authors: Goldman Et al.
    Nat Commun 2015;6:6139
  3. Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin Lymphomas.
    Authors: Knutson Et al.
    PLoS One 2014;9:e111840
  4. Synergistic effects of oncolytic reovirus and docetaxel chemotherapy in prostate cancer.
    Authors: Heinemann Et al.
    Sci Rep 2011;11:221

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