ML 7 hydrochloride

  ( 5 citations )    
Product Datasheet
Catalog Number:4310
Chemical Name:Hexahydro-1-[(5-iodo-1-naphthalenyl)sulfonyl]-1H-1,4-diazepine hydrochloride
Product Details
Citations (5)
Reviews
Biological Activity
Selective MLCK inhibitor (Ki = 0.3 μM). Exhibits more potent inhibition than ML 9 hydrochloride (Cat. No. 0431) Displays reversible, ATP-competitive inhibition of Ca2+-calmodulin-dependent and -independent smooth muscle MLCKs. Inhibits proplatelet formation and stabilization.
Technical Data
  • M.Wt:
    452.74
  • Formula:
    C15H17IN2O2S.HCl
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at -20°C
  • CAS No:
    110448-33-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for ML 7 hydrochloride include:

5 Citations: Showing 1 - 5
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  1. αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin.
    Authors: Bharadwaj
    Nat Commun  2017;8:14348
  2. Sustained Contraction in Vascular Smooth Muscle by Activation of L-type Ca2+ Channels Does Not Involve Ca2+ Sensitization or Caldesmon.
    Authors: Ets
    Front Pharmacol  2016;7:516
  3. Substrate stress relaxation regulates cell spreading.
    Authors: Chaudhuri Et al.
    J Neurosci  2015;6:6364
  4. Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair.
    Authors: Leoni Et al.
    J Clin Invest  2015;125:1215
  5. An essential role for inhibitor-2 regulation of protein phosphatase-1 in synaptic scaling.
    Authors: Siddoway Et al.
    Am J Physiol Renal Physiol  2013;33:11206

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