Catalog Number: 4310
Chemical Name: Hexahydro-1-[(5-iodo-1-naphthalenyl)sulfonyl]-1H-1,4-diazepine hydrochloride
Biological Activity
Selective MLCK inhibitor (Ki = 0.3 μM). Exhibits more potent inhibition than ML 9 hydrochloride (Cat. No. 0431) Displays reversible, ATP-competitive inhibition of Ca2+-calmodulin-dependent and -independent smooth muscle MLCKs. Inhibits proplatelet formation and stabilization.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Selective inhibition of catalytic activity of smooth muscle myosin light chain kinase.
    Saitoh et al.
    J.Biol.Chem., 1987;262:7796
  2. Sp1/Sp3 transcription factors regulate hallmarks of megakaryocyte maturation and platelet formation and function.
    Meinders et al.
    Blood, 2015;125:1957

The citations listed below are publications that use Tocris products. Selected citations for ML 7 hydrochloride include:

Showing Results 1 - 3 of 3

  1. Substrate stress relaxation regulates cell spreading.
    Authors: Chaudhuri Et al.
    J Neurosci
  2. Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair.
    Authors: Leoni Et al.
    J Clin Invest
  3. An essential role for inhibitor-2 regulation of protein phosphatase-1 in synaptic scaling.
    Authors: Siddoway Et al.
    Am J Physiol Renal Physiol
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