Catalog Number: 4310
Chemical Name: Hexahydro-1-[(5-iodo-1-naphthalenyl)sulfonyl]-1H-1,4-diazepine hydrochloride
Biological Activity
Selective MLCK inhibitor (Ki = 0.3 μM). Exhibits more potent inhibition than ML 9 hydrochloride (Cat. No. 0431) Displays reversible, ATP-competitive inhibition of Ca2+-calmodulin-dependent and -independent smooth muscle MLCKs. Inhibits proplatelet formation and stabilization.
Technical Data
  • M.Wt:
    452.74
  • Formula:
    C15H17IN2O2S.HCl
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at -20°C
  • CAS No:
    110448-33-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Selective inhibition of catalytic activity of smooth muscle myosin light chain kinase.
    Saitoh et al.
    J.Biol.Chem., 1987;262:7796
  2. Sp1/Sp3 transcription factors regulate hallmarks of megakaryocyte maturation and platelet formation and function.
    Meinders et al.
    Blood, 2015;125:1957
Citations:

The citations listed below are publications that use Tocris products. Selected citations for ML 7 hydrochloride include:

5 Citations: Showing 1 - 5
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  1. αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin.
    Authors: Bharadwaj
    Nat Commun 2017;8:14348
  2. Sustained Contraction in Vascular Smooth Muscle by Activation of L-type Ca2+ Channels Does Not Involve Ca2+ Sensitization or Caldesmon.
    Authors: Ets
    Front Pharmacol 2016;7:516
  3. Substrate stress relaxation regulates cell spreading.
    Authors: Chaudhuri Et al.
    J Neurosci 2015;6:6364
  4. Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair.
    Authors: Leoni Et al.
    J Clin Invest 2015;125:1215
  5. An essential role for inhibitor-2 regulation of protein phosphatase-1 in synaptic scaling.
    Authors: Siddoway Et al.
    Am J Physiol Renal Physiol 2013;33:11206

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