ML 7 hydrochloride

Catalog # Availability Size / Price Qty
4310/10
4310/50
ML 7 hydrochloride | CAS No. 110448-33-4 | Myosin Light Chain Kinase Inhibitors
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Description: Selective inhibitor of myosin light chain kinase

Chemical Name: Hexahydro-1-[(5-iodo-1-naphthalenyl)sulfonyl]-1H-1,4-diazepine hydrochloride

Purity: ≥99%

Product Details
Citations (7)
Reviews (2)

Biological Activity

ML 7 hydrochloride is a selective MLCK inhibitor (Ki = 0.3 μM). Exhibits more potent inhibition than ML 9 hydrochloride (Cat. No. 0431) Displays reversible, ATP-competitive inhibition of Ca2+-calmodulin-dependent and -independent smooth muscle MLCKs. Inhibits proplatelet formation and stabilization.

Technical Data

M.Wt:
452.74
Formula:
C15H17IN2O2S.HCl
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
110448-33-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for ML 7 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for ML 7 hydrochloride include:

7 Citations: Showing 1 - 7

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Reviews for ML 7 hydrochloride

Average Rating: 4.5 (Based on 2 Reviews)

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Works well
By Wen Ding on 08/04/2020
Application: Species: Mouse

Mouse from all two groups were housed in condition of a 12 -h shift of light–dark cycle. Mouse of the control group were fed a normal diet, the ML7 group was fed orally treated with ML7 (1 mg/kg daily)


ML7 is good for polarization
By Anonymous on 09/12/2019
Application: Species: Mouse

Bright-field (top) images for tetON-Snai1 MEOs treated with doxycycline and 10 μM ML7 for four days.


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