ML 7 hydrochloride
Chemical Name: Hexahydro-1-[(5-iodo-1-naphthalenyl)sulfonyl]-1H-1,4-diazepine hydrochloride
Biological ActivityML 7 hydrochloride is a selective MLCK inhibitor (Ki = 0.3 μM). Exhibits more potent inhibition than ML 9 hydrochloride (Cat. No. 0431) Displays reversible, ATP-competitive inhibition of Ca2+-calmodulin-dependent and -independent smooth muscle MLCKs. Inhibits proplatelet formation and stabilization.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Selective inhibition of catalytic activity of smooth muscle myosin light chain kinase.
Saitoh et al.
Sp1/Sp3 transcription factors regulate hallmarks of megakaryocyte maturation and platelet formation and function.
Meinders et al.
Citations for ML 7 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for ML 7 hydrochloride include:
7 Citations: Showing 1 - 7
Volume expansion and TRPV4 activation regulate stem cell fate in three-dimensional microenvironments.
Authors: Lee Et al.
Nat Commun 2019;10:529
Actomyosin-Mediated Tension Orchestrates Uncoupled Respiration in Adipose Tissues.
Authors: Tharp Et al.
Cell Metab 2018;27:602
αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin.
Nat Commun 2017;8:14348
Sustained Contraction in Vascular Smooth Muscle by Activation of L-type Ca2+ Channels Does Not Involve Ca2+ Sensitization or Caldesmon.
Front Pharmacol 2016;7:516
Substrate stress relaxation regulates cell spreading.
Authors: Chaudhuri Et al.
J Neurosci 2015;6:6364
Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair.
Authors: Leoni Et al.
J Clin Invest 2015;125:1215
An essential role for inhibitor-2 regulation of protein phosphatase-1 in synaptic scaling.
Authors: Siddoway Et al.
Am J Physiol Renal Physiol 2013;33:11206
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Mouse from all two groups were housed in condition of a 12 -h shift of light–dark cycle. Mouse of the control group were fed a normal diet, the ML7 group was fed orally treated with ML7 (1 mg/kg daily)
Bright-field (top) images for tetON-Snai1 MEOs treated with doxycycline and 10 μM ML7 for four days.