ML 7 hydrochloride

Tocris Bioscience | Catalog # 4310

Selective inhibitor of myosin light chain kinase
Tocris Bioscience

Key Product Details

Description

Selective inhibitor of myosin light chain kinase
View all Myosin Light Chain Kinase Inhibitors »

Product Description

ML 7 hydrochloride is a selective MLCK inhibitor (Ki = 0.3 μM). Exhibits more potent inhibition than ML 9 hydrochloride (Cat. No. 0431) Displays reversible, ATP-competitive inhibition of Ca2+-calmodulin-dependent and -independent smooth muscle MLCKs. Inhibits proplatelet formation and stabilization.

Product Specifications for ML 7 hydrochloride

Molecular Weight

452.74

Formula

C15H17IN2O2S.HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

Hexahydro-1-[(5-iodo-1-naphthalenyl)sulfonyl]-1H-1,4-diazepine hydrochloride

CAS Number

110448-33-4

PubChem ID

9803932

InChI Key

KDDALCDYHZIZMH-UHFFFAOYSA-N

SMILES

IC1=C(C=CC=C2S(N3CCCNCC3)(=O)=O)C2=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.64 50

Preparing Stock Solutions for ML 7 hydrochloride

The following data is based on the product molecular weight 452.74.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.42 mL 22.09 mL 44.18 mL
2.5 mM 0.88 mL 4.42 mL 8.84 mL
5 mM 0.44 mL 2.21 mL 4.42 mL
25 mM 0.09 mL 0.44 mL 0.88 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

x
=
x

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 25 publications citing the usage of this product.

Product Documents for ML 7 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for ML 7 hydrochloride

For research use only

Citations for ML 7 hydrochloride

Customer Reviews for ML 7 hydrochloride (2)

4.5 out of 5
2 Customer Ratings
5 Stars
50%
4 Stars
50%
3 Stars
0%
2 Stars
0%
1 Stars
0%

Have you used ML 7 hydrochloride?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review
Amazon Gift Card

Customer Images

Showing  1 - 2 of 2 reviews Showing All
Filter By:
Clear Filters X
  • Works well
    Name: Wen Ding
    Species: Mouse
    Assay Type: In Vivo
    Cell Line/Tissue: aorta
    Verified Customer | Posted 08/04/2020
    Mouse from all two groups were housed in condition of a 12 -h shift of light–dark cycle. Mouse of the control group were fed a normal diet, the ML7 group was fed orally treated with ML7 (1 mg/kg daily)
    ML 7 hydrochloride 4310
  • ML7 is good for polarization
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: primary MEO
    Verified Customer | Posted 09/12/2019
    Bright-field (top) images for tetON-Snai1 MEOs treated with doxycycline and 10 μM ML7 for four days.
    ML 7 hydrochloride 4310

There are no reviews that match your criteria.

Showing  1 - 2 of 2 reviews Showing All