MMP-12 Antibody (701E4.03) - Azide and BSA Free

Novus Biologicals | Catalog # DDX0284P-100

Novus Biologicals

Key Product Details

Species Reactivity

Human

Applications

Western Blot, ELISA, Immunoprecipitation

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # 701E4.03

Format

Azide and BSA Free
View all MMP-12 Primary Antibodies »

Product Specifications

Immunogen

MMP-12/HME was used as immunogen.

Reactivity Notes

Human

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for MMP-12 Antibody (701E4.03) - Azide and BSA Free

ELISA: MMP-12 Antibody (701E4.03) [DDX0284P-100]

ELISA: MMP-12 Antibody (701E4.03) [DDX0284P-100]

ELISA: MMP-12 Antibody (701E4.03) [DDX0284P-100] - 1= control2= HME-transfected cells3= CD34++GMCSF+TNF- +IL44= patient serum of Langerhans histiocytosis

Applications for MMP-12 Antibody (701E4.03) - Azide and BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunoprecipitation

1:10-1:500

Western Blot

1:100-1:2000

Formulation, Preparation, and Storage

Purification

Ion exchange chromatography

Formulation

Tris-NaCl (pH 8.0)

Format

Azide and BSA Free

Preservative

No Preservative

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: MMP-12

Human macrophage elastase (MMP-12) is a member of the family of matrix metalloproteinases (MMPs) that plays, like other members of the family, an important role in inflammatory processes contributing to tissue remodeling and destruction. In particular, a prominent role of MMP-12 in the destruction of elastin in the lung alveolar wall and the pathogenesis of emphysema has been suggested. It is therefore an attractive therapeutic target (1). MMP-12) expressed mainly in alveolar macrophages has been identified in the mouse lung as the main destructive agent associated with cigarette smoking, which gives rise to emphysema, both directly via elastin degradation and indirectly by disturbing the proteinase/antiproteinase balance via inactivation of the alpha1-proteinase inhibitor (alpha1-PI), the antagonist of the leukocyte elastase (2). Because elastin represents a critical component of aortic wall structure and a matrix substrate for metalloelastases, MMP-12 may have a direct and singular role in the pathogenesis of aortic aneurysms (3).

Long Name

Matrix Metalloproteinase 12

Alternate Names

MMP12

Gene Symbol

MMP12

Additional MMP-12 Products

Product Documents for MMP-12 Antibody (701E4.03) - Azide and BSA Free

Certificate of Analysis

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Product Specific Notices for MMP-12 Antibody (701E4.03) - Azide and BSA Free

This product is manufactured by Eurobio Scientific (formerly Dendritics) and distributed by Novus Biologicals.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Metalloproteases and Regulators

Citations for MMP-12 Antibody (701E4.03) - Azide and BSA Free

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