Catalog Number: 5770
Chemical Name: 2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitro-benzoic acid
Biological Activity
Potent TMEM16A (Anoctamin-1) blocker (IC50 = 80 nM). Exhibits >100-fold selectivity for TMEM16A over bestrophin-1, CLC2 and CFTR. Induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions.
Technical Data
  • M.Wt:
    338.31
  • Formula:
    C18H14N2O5
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    1572936-83-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. MONNA, a potent and selective blocker for transmembrane protein with unknown function 16/anoctamin-1.
    Oh et al.
    Mol.Pharmacol., 2013;84:726
  2. New selective inhibitors of calcium-activated chloride channels - T16A(inh) -A01, CaCC(inh) -A01 and MONNA - what do they inhibit?
    Boedtkjer et al.
    Br.J.Pharmacol., 2015;172:4158
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