Chemical Name: 2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitro-benzoic acid
Biological ActivityMONNA is a potent TMEM16A (Anoctamin-1) blocker (IC50 = 80 nM). Exhibits >100-fold selectivity for TMEM16A over bestrophin-1, CLC2 and CFTR. Induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions. Carbachol (Cat. No. 2810) induced contraction of bronchial myocytes is reduced by MONNA and intracellular calcium release is increased.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
MONNA, a potent and selective blocker for transmembrane protein with unknown function 16/anoctamin-1.
Oh et al.
New selective inhibitors of calcium-activated chloride channels - T16A(inh) -A01, CaCC(inh) -A01 and MONNA - what do they inhibit?
Boedtkjer et al.
Citation for MONNA
The citations listed below are publications that use Tocris products. Selected citations for MONNA include:
1 Citation: Showing 1 - 1
The TMEM16A blockers benzbromarone and MONNA cause intracellular Ca2+-release in mouse bronchial smooth muscle cells
Authors: Dwivedi Et al.
Eur J Pharmacol 2023;
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