Potent TMEM16A (Anoctamin-1) blocker (IC50
= 80 nM). Exhibits >100-fold selectivity for TMEM16A over bestrophin-1, CLC2 and CFTR. Induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions.
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MONNA, a potent and selective blocker for transmembrane protein with unknown function 16/anoctamin-1.
Oh et al.
New selective inhibitors of calcium-activated chloride channels - T16A(inh) -A01, CaCC(inh) -A01 and MONNA - what do they inhibit?
Boedtkjer et al.