Mouse 4-1BB/TNFRSF9/CD137 (NP_035742) VersaClone cDNA Summary
4-1BB, also known as CD137 and TNFRSF9, is a transmembrane TNF receptor superfamily member that is expressed as on various populations of activated T cell including CD4+, CD8+, memory CD8+, NKT, and regulatory T cells as well as on myeloid and mast cell progenitors, dendritic cells, mast cells, and bacterially infected osteoblasts. 4-1BB binding by 4-1BB Ligand costimulates T cell proliferation, activation, and/or survival and can enhance the activation-induced cell death of repetitively stimulated T cells. 4-1BB can associate with OX40 on activated T cells, forming a complex that responds to either ligand and inhibits Treg and CD8+ T cell proliferation. Reverse signaling through 4-1BB Ligand inhibits the development of dendritic cells, B cells, and osteoclasts but supports mature dendritic cell survival and costimulates the proliferation and activation of mast cells.
No product specific FAQs exist for this product, however you mayView all cDNA Clone FAQs
Reviews for Mouse 4-1BB/TNFRSF9/CD137 (NP_035742) VersaClone cDNA
There are currently no reviews for this product. Be the first to review Mouse 4-1BB/TNFRSF9/CD137 (NP_035742) VersaClone cDNA and earn rewards!
Have you used Mouse 4-1BB/TNFRSF9/CD137 (NP_035742) VersaClone cDNA?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image