Mouse CCR5 Alexa Fluor® 647-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: CCR5

CCR5 (CC chemokine receptor 5; also CD195 and MIP-1a receptor) is a 41 - 44 kDa member of the G-protein coupled receptor #1 family of proteins.  It is expressed on Treg cells, NK cells, neurons, macrophages and Th1 cells. CCR5 mediates cell adhesion and migration induced by several chemokines including CCL3/MIP-1 alpha, CCL4/MIP-1 beta, CCL5/RANTES, and CCL8/MCP-2. It also functions as a coreceptor for macrophage-tropic HIV-1 infection. CCR5 contains an O-glycosylated and sulfated extracellular N-terminus (aa 1 - 32), and a phosphorylated and palmitoylated intracellular C-terminus (aa 304 - 354).  CCR5 will form homodimers, heterodimers with CCR2, and heterooligomers with CCR2 and CXCR4. Within aa 1 - 32, mouse CCR5 shares 72% and 91% amino acid sequence identity with human and rat CCR5, respectively.

Product Datasheets

Related Research Areas

• CC Chemokines and Receptors
• Chemokine Receptors
• Chemokines and Receptors in Angiogenesis
• Common Macrophage Markers
• Cytokine and Growth Factor Receptors on VSMC
• G Protein-Coupled Receptors in Immune Responses
• gamma delta T Cells
• Infectious Diseases
• Monocyte Markers
• Multiple Myeloma
• Receptors in the Jak/STAT Pathway
• Regulatory T Cells (Tregs)
• T Cell Migration/Adhesion
• Th1 Cells