Mouse CD302/CLEC13A Alexa Fluor® 750-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: CD302/CLEC13A

CD302 (also DCL-1 and CLEC13A) is a 31-36 kDa member of the C-type lectin domain family of proteins. It is expressed on cells involved in phagocytosis, including neutrophils, monocytes, dendritic cells and macrophages. CD302 is suggested to facilitate phagocytosis, and participate in cell adhesion and migration. Mature mouse CD302 is a 208 amino acid (aa) type I transmembrane glycoprotein. It contains a 146 aa extracellular domain (ECD) (aa 21-165) plus a 42 aa cytoplasmic region. The ECD possesses one C-type lectin domain (aa 30-149) that apparently cannot bind carbohydrate. In human, CD302 has also been detected in dendritic cells as the C-terminal portion of a 215 kDa fusion protein that involves DEC205. CD302 contributes aa 23-232 to this fusion protein. Mouse CD302 has two potential splice variants. One shows an alternative start site at Met61, while another shows a deletion of aa 154-162. Over aa 21-165, mouse CD302 shares 82% and 92% aa identity with human and rat CD302, respectively.

Product Datasheets

Related Research Areas

• C-type Lectin Family