|CDO in Mouse Embryo. CDO was detected in immersion fixed frozen sections of mouse embryo (13 d.p.c.) using Goat Anti-Mouse CDO Biotinylated Antigen Affinity-purified Polyclonal Antibody (Catalog # BAF2429) at 1.7 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). Specific staining was localized to developing central nervous system, cartilage and muscle cells. View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections.|
Mouse CDO is a 190 kDa member of the Ig/FN-type III repeat subfamily of transmembrane (TM) proteins. The extracellular region contains five Ig-like domains and three FN-III modules. The molecule forms cis-complexes with itself and the related molecule termed BOC. Mouse CDO extracellular domain shares 95% and 85% aa identity with the corresponding regions of rat and human CDO, respectively.
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