Mouse Coagulation Factor XIV/Protein C Biotinylated Antibody
Mouse Coagulation Factor XIV/Protein C Biotinylated Antibody Summary
Accession # P33587
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Coagulation Factor XIV/Protein C
Protein C is a vitamin K-dependent serine protease synthesized in the liver as a single-chain precursor, which is then proteolytically processed to two disulfide-linked chains (1). The light chain consists of a Gla (gamma-carboxy-glutamate) domain and two EGF-like domains. The heavy chain consists of an activation peptide (aa 199‑212) and serine protease domain (aa 213‑449). Physiologically, Protein C is converted to the active form by thrombin, which releases the activation peptide. Protein C plays a key role in anticoagulation, cleaving factors VIIIa and Va to inactivate them. This anticoagulation activity can be enhanced by a presence of a cofactor such as protein S. In hereditary thrombophilia, Protein C deficiency is caused by a genetic mutation that affects Protein C activity. A severe recessive form may result in massive thrombosis fatal to patient.
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