Mouse CX3CL1/Fractalkine (NP_033168) VersaClone cDNA

Name: Mouse CX3CL1/Fractalkine (NP_033168) VersaClone cDNA
Brand: R&D Systems
SKU: RDC2969
Price: 270 USD
Availability: InStock

R&D Systems | Catalog # RDC2969

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Product Documents

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Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species

Mouse

Accession Number

NP_033168

Formulation, Preparation, and Storage

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: CX3CL1/Fractalkine

CX3CL1/Fractalkine is a transmembrane adhesion protein with a chemokine domain separated from the membrane by a mucin stalk. It is upregulated on many cell types during inflammation. The chemokine and mucin regions can be shed as a soluble chemokine that signals through the receptor CX3CR1. During extravasation, membrane-bound CX3CL1 traps leukocytes, then is cleaved to allow diapedesis. Soluble CX3CL1 protects neurons from microglial neurotoxicity, recruits macrophages for wound healing, recruits osteoclast precursors for bone resorption, and contributes to pathogenesis in coronary artery disease.