Mouse FOLR4 Alexa Fluor® 350-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: FOLR4

FOLR4 (folate receptor 4; also FR4, FR-d and FOLBP-3) is a 35 kDa glycoprotein member of the folate receptor family. It is found on mouse Treg cells, particularly those classified as natural, and CD4⁺ CD25^- T cells that produce low amounts of IFN-gamma. Although folate family receptors can internalize folate, they are generally not the principal conduits for folate uptake. Mouse FOLR4 preproprecursor is 244 amino acids (aa) in length. It contains a 19 aa signal sequence plus a 225 aa proform. While there are no definitive structural motifs, there is presumably a C-terminal propeptide that gives rise to a GPI-linkage. There are three potential isoforms. One is 37 kDa in size and shows a 36 aa insertion after Glu155. Two others show a deletion of  aa 47-109, and a 17 aa substitution for aa 157-244. Over aa 20-100, mouse FOLR4 shares 84% and 70% aa identity with rat and human FOLR4, respectively.

Product Datasheets

Related Research Areas

• Cancer Biomarkers