GPR31 is a plasma membrane G protein-coupled receptor (GPCR) that displays high affinity for 12-lipoxygenase-derived product 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-(S)-HETE). Knocking down GPR31 specifically inhibited 12-(S)-HETE-stimulated cell invasion. The diverse biological activities mediated by 12-(S)-HETE suggest that it functions as a critical signaling molecule in the regulation of physiological processes. 12-(S)-HETE/GPR31 binding leads to the activation of ERK1/2, MEK, and NF-kB.
Mouse GPR31 (NP_001013854) VersaClone cDNA
R&D Systems | Catalog # RDC0649
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Background: GPR31
Long Name
G-Protein-Coupled Receptor 31
Alternate Names
12-HETER, HETER1
Gene Symbol
GPR31
UniProt
Additional GPR31 Products
Product Documents for Mouse GPR31 (NP_001013854) VersaClone cDNA
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Product Specific Notices for Mouse GPR31 (NP_001013854) VersaClone cDNA
For research use only
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