Mouse IFN-beta Antibody

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Product Details
Citations (4)

Mouse IFN-beta Antibody Summary

Species Reactivity
Mouse IFN-beta
Polyclonal Rabbit Serum
Antigen Affinity-purified
E. coli-derived recombinant mouse IFN-beta
Neat serum diluted in phosphate buffered saline (PBS)


Recommended Concentration
One neutralization unit is the amount of antiserum required to neutralize one unit of mouse interferon beta (Mu-IFN-beta ) to a 50% endpoint. Interferon was titrated with the use of the cytopathic effect inhibition assay [Rubinstein, S., Familletti, P.C., and Pestka, S. (1981) J. Virol. 37, 755-758] using L929 cells and EMCV as the challenge virus. In this antiviral assay for interferon, about 2.5 unit/ml of interferon is the quantity necessary to produce a cytopathic effect of 50%. The units are determined by use of a laboratory standard calibrated with respect to the international reference standard for Mu-IFN-beta provided by the National Institutes of Health [Gb02-902-511]. This material is prepared specifically for effective neutralization of Mu-IFN-beta.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
After receipt, this product should be kept at -70˚C or below for retention of full activity.Thaw product vial by incubation in cold tap water until just thawed – the contents of the tube should be apportioned in separate tubes so that freezing and thawing is kept to a minimum. Refreezing should be done on dry ice or in a dry ice/alcohol bath.

Background: IFN-beta

Interferon-beta (IFN-beta) is a cytokine that is produced by fibroblasts and pathogen-exposed dendritic cells, macrophages, and endothelial cells. It signals through the heterodimeric IFN-alpha/beta Receptor. IFN-beta-deficient mice show increased susceptibility to experimental autoimmune encephalomyelitis (EAE), a disease model of human multiple sclerosis (MS). Furthermore, IFN-beta has been shown to suppress the Th17 cell response in both MS and EAE and has commonly been used as a treatment for MS.

Long Name
Interferon beta
Entrez Gene IDs
3456 (Human); 15977 (Mouse); 24481 (Rat)
Alternate Names
Fibroblast interferon; IFB; IFBIFNB; IFF; IFNB; IFNB1; IFNbeta; IFN-beta; interferon beta; interferon, beta 1, fibroblast; MGC96956

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Citations for Mouse IFN-beta Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

4 Citations: Showing 1 - 4
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  1. ZBP1 promotes inflammatory responses downstream of TLR3/TLR4 via timely delivery of RIPK1 to TRIF
    Authors: HI Muendlein, WM Connolly, Z Magri, D Jetton, I Smirnova, A Degterev, S Balachandr, A Poltorak
    Proceedings of the National Academy of Sciences of the United States of America, 2022-06-06;119(24):e2113872119.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: ELISA Capture
  2. Constitutive Interferon Maintains GBP Expression Required for Release of Bacterial Components Upstream of Pyroptosis and Anti-DNA Responses
    Authors: BC Liu, J Sarhan, A Panda, HI Muendlein, V Ilyukha, J Coers, M Yamamoto, RR Isberg, A Poltorak
    Cell Rep, 2018-07-03;24(1):155-168.e5.
    Species: Human, Mouse
    Sample Types: Cell Culture Supernates
    Applications: ELISA Development (Detection)
  3. Evaluating vaccinia virus cytokine co-expression in TLR GKO mice.
    Authors: Sutherland DB, Ranasinghe C, Regner M, Phipps S, Matthaei KI, Day SL, Ramshaw IA
    Immunol. Cell Biol., 2010-12-21;89(0):706-15.
    Species: Mouse
    Sample Types: Serum
    Applications: ELISA Development
  4. A role for Stat1 in the regulation of lipopolysaccharide-induced interleukin-1beta expression.
    Authors: Joshi VD, Kalvakolanu DV, Chen W, Zhang L, Kang TJ, Thomas KE, Vogel SN, Cross AS
    J. Interferon Cytokine Res., 2006-10-01;26(10):739-47.
    Species: Mouse
    Sample Types: Serum
    Applications: ELISA Development


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