Mouse IGSF2/CD101 APC‑conjugated Antibody

IGSF2, also known as CD101 and V7 is a 135-140 kDa member of the EWI family, Ig superfamily of molecules. It is a type I transmembrane glycoprotein that is expressed on dermal dendritic cells (DCs), granulocytes, monocytes, activated T cells, and Tregs. IGSF2 ligation is involved in T cell activation. On dermal DCs, CD101 ligation induces IL-10 expression, and on activated T cells, CD101 ligation blocks IL-2 expression, two effects that downregulate T cell activity. Notably, in mouse, CD101 expression on CD62L⁺⁺ Tregs identifies a population of cells that have potent suppressor activity. The extracellular domain of mouse shares 86% and 69% amino acid sequence identity with the ECD of rat and human CD101, respectively.