Mouse IL-17 Quantikine HS ELISA Kit
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Mouse IL-17 Quantikine HS ELISA Kit Summary
The recovery of mouse IL-17 spiked to levels throughout the range of the assay in various matrices was evaluated.
|Average % Recovery
|EDTA Plasma (n=4)
|Heparin Plasma (n=4)
Mouse IL-17 Quantikine HS ELISA Standard Curve
Preparation and Storage
The IL-17 family is comprised of at least six proinflammatory cytokines that share a conserved cysteine-knot structure but diverge at the N-terminus. IL-17 family members are glycoproteins secreted as dimers that induce local cytokine production and recruit granulocytes to sites of inflammation. IL-17 is induced by IL-15 and IL-23, mainly in activated CD4+ T cells distinct from Th1 or Th2 cells. IL-17F is the most homologous to IL-17, but is induced only by IL-23 in activated monocytes. IL-17B binds the IL-17B receptor, but not the IL-17 receptor; it is most homologous with IL-17D, which is expressed by resting CD4+ T cells and CD19+ B cells. IL-17E is mainly produced by Th2 cells and recruits eosinophils to lung tissue. IL-17C has a very restricted expression pattern but has been detected in adult prostate and fetal kidney libraries.
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