Mouse Integrin beta 3/CD61 Alexa Fluor® 700-conjugated Antibody
Mouse Integrin beta 3/CD61 Alexa Fluor® 700-conjugated Antibody Summary
Leu32-Arg988 (Integrin alpha 2b) & Glu26-Asp717 (Integrin beta 3)
Accession # NP_034705 (Integrin alpha 2b) & O54890 (Integrin beta 3)
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
Background: Integrin beta 3/CD61
Integrin beta 3 (ITGB3) is also known as platelet glycoprotein IIIa (GPIIIa) and CD61. Integrins are integral cell-surface proteins known to participate in both cell adhesion and cell-surface mediated signaling. They are composed of an alpha chain and a beta chain. ITGB3 is an integrin beta chain that forms a heterodimer with alpha-IIb or alpha-V chains. It is involved in platelet aggregation, and serves as an anchor for fibrinogen, allowing platelets to form aggregates or clots. A functional absense of ITGB3 leads to Glanzmann's thrombasthenia, a condition where platelets are activated, but fail to form an aggregate. Alternatively spliced transcripts encoding different proteins have been described, in human.
Product Specific Notices
This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.
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