JMJD6 (Jumonji [Japanese for "cruciform/cross"] domain-containing protein 6; also PTDSR/PSR and Lysyl-hydroxylase JMJD6) is a 47-55 kDa member of the JMJD6 family, cupin superfamily of proteins. It is induced by hypoxia, and expressed in skeletal muscle, macrophages and possibly endothelial cells. JMJD6 is reported to demethylate histones (which it does not), serve as a phosphatidyl serine receptor (which it might), and act as a lysyl hydroxylase (which it does). In the nucleus, it appears to regulate pre-RNA splicing by hydroxylating various splicing factors such as U2AF65. Mouse JMJD6 is 403 amino acids (aa) in length. It contains five NLS's plus a JmjC domain (aa 141-305) and three iron-based catalytic sites. There at least three potential isoform variants. One contains a 29 aa substitution for aa 270‑403, a second possesses a 30 aa substitution for aa 302-314, and a third shows a 21 aa substitution for aa 315-403. JMJD6 is known to form high MW homo‑trimers, -tetramers and -oligomers. Full-length mouse JMJD6 shares 98% and 99% aa sequence identity with human and rat JMJD6, respectively.
Mouse JMJD6/PSR Alexa Fluor® 647‑conjugated Antibody
R&D Systems | Catalog # AF1994R
Key Product Details
Species Reactivity
Applications
Label
Antibody Source
Product Specifications
Immunogen
Ala289-Arg403
Accession # Q9ERI5
Specificity
Clonality
Host
Isotype
Applications for Mouse JMJD6/PSR Alexa Fluor® 647‑conjugated Antibody
Western Blot
Formulation, Preparation, and Storage
Purification
Formulation
Shipping
Stability & Storage
Background: JMJD6/PSR
Long Name
Alternate Names
Gene Symbol
UniProt
Additional JMJD6/PSR Products
Product Documents for Mouse JMJD6/PSR Alexa Fluor® 647‑conjugated Antibody
Certificate of Analysis
To download a Certificate of Analysis, please enter a lot or batch number in the search box below.
Note: Certificate of Analysis not available for kit components.
Product Specific Notices for Mouse JMJD6/PSR Alexa Fluor® 647‑conjugated Antibody
This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.
For research use only
Related Research Areas
Customer Reviews for Mouse JMJD6/PSR Alexa Fluor® 647‑conjugated Antibody
There are currently no reviews for this product. Be the first to review Mouse JMJD6/PSR Alexa Fluor® 647‑conjugated Antibody and earn rewards!
Have you used Mouse JMJD6/PSR Alexa Fluor® 647‑conjugated Antibody?
Submit a review and receive an Amazon gift card!
$25/€18/£15/$25CAN/¥2500 Yen for a review with an image
$10/€7/£6/$10CAN/¥1110 Yen for a review without an image
Submit a review
Protocols
Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.
- Cellular Response to Hypoxia Protocols
- R&D Systems Quality Control Western Blot Protocol
- Troubleshooting Guide: Western Blot Figures
- Western Blot Conditions
- Western Blot Protocol
- Western Blot Protocol for Cell Lysates
- Western Blot Troubleshooting
- Western Blot Troubleshooting Guide
- View all Protocols, Troubleshooting, Illustrated assays and Webinars