NKp30/NCR3, NKp44/NCR2, and NKp46/NCR1 are termed natural cytotoxicity receptors (NCR). These receptors are type I transmembrane proteins with 1-2 extracellular immunoglobulin domains, a transmembrane domain containing a positively charged amino acid residue, and a short cytoplasmic tail. All are expressed almost exclusively by NK cells and play a major role in triggering NK-mediated killing of most tumor cell lines. NKp44 is induced upon activation of resting NK cells with IL-2 and can bind to viral hemagglutinins. NK-mediated dendritic cell (DC) recognition is highly dependent on engagement of NKp30 and may result in lysis of the DC.
Mouse NKp46/NCR1 (AAI15365) VersaClone cDNA
R&D Systems | Catalog # RDC2170
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Formulation, Preparation, and Storage
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: NKp46/NCR1
Alternate Names
CD335, Ly94, MAR-1, NCR1
Gene Symbol
NCR1
UniProt
Additional NKp46/NCR1 Products
Product Documents for Mouse NKp46/NCR1 (AAI15365) VersaClone cDNA
Certificate of Analysis
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Note: Certificate of Analysis not available for kit components.
Product Specific Notices for Mouse NKp46/NCR1 (AAI15365) VersaClone cDNA
For research use only
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Associated Pathways
Innate Lymphoid Cell Differentiation Pathways
