Mouse Pref-1/DLK1/FA1 APC-conjugated Antibody
Mouse Pref-1/DLK1/FA1 APC-conjugated Antibody Summary
Ala24-Gln305
Accession # Q09163
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of Pref‑1/DLK1/FA1 in 3T3‑L1 Mouse Cell Line by Flow Cytometry. 3T3-L1 mouse embryonic fibroblast adipose-like cell line was stained with Rabbit Anti-Mouse Pref-1/DLK1/FA1 APC-conjugated Monoclonal Antibody (Catalog # FAB8634A, filled histogram) or isotype control antibody (Catalog # IC105A, open histogram). View our protocol for Staining Membrane-associated Proteins.
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Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: Pref-1/DLK1/FA1
Pref-1 (Preadipocyte factor 1), also known as Protein delta homolog 1, DLK1, FA1 and Fetal antigen 1, is a 45-60 kDa transmembrane glycoprotein that is highly expressed in fetal liver, placenta, adult adrenal gland, brain, testis and ovary. Expression of Pref-1 is elevated in liver after birth but starts to decline around postnatal day 16. Mature mouse Pref-1 is a 362 amino acid (aa) type I transmembrane N- and O-linked glycoprotein. It contains a 282 aa extracellular region (aa 24-305), a 24 aa transmembrane segment (aa 306-329), and a 56 aa cytoplasmic domain (aa 330-385). It contains 6 EGF-like domains and is involved in embryonic skeletal system development. Pref-1 inhibits preadipocyte proliferation by regulating their entry into G1/S-phase and represses preadipocyte differentiation. It is a master regulator of preadipocyte homeostasis and adipose tissue expansion. Pref-1 manipulation may, therefore, be utilized in obesity treatments. Mouse Pref-1 shares 85% and 94% aa identity with human and rat Pref-1, respectively.
Product Datasheets
Citations for Mouse Pref-1/DLK1/FA1 APC-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 3
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Tcf21 marks visceral adipose mesenchymal progenitors and functions as a rate-limiting factor during visceral adipose tissue development
Authors: Q Liu, C Li, B Deng, P Gao, L Wang, Y Li, M Shiri, F Alkaifi, J Zhao, JM Stephens, CA Simintiras, J Francis, J Sun, X Fu
Cell Reports, 2023-02-28;42(3):112166.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Prrx1 Fibroblasts Represent a Pro-fibrotic Lineage in the Mouse Ventral Dermis
Authors: T Leavitt, MS Hu, MR Borrelli, M Januszyk, JT Garcia, RC Ransom, S Mascharak, HE desJardins, UM Litzenburg, GG Walmsley, CD Marshall, AL Moore, B Duoto, S Adem, DS Foster, A Salhotra, AH Shen, M Griffin, EZ Shen, LA Barnes, ER Zielins, ZN Maan, Y Wei, CKF Chan, DC Wan, HP Lorenz, HY Chang, GC Gurtner, MT Longaker
Cell Rep, 2020-11-10;33(6):108356.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Single-cell RNA-Seq analysis reveals dynamic trajectories during mouse liver development
Authors: X Su, Y Shi, X Zou, ZN Lu, G Xie, JYH Yang, CC Wu, XF Cui, KY He, Q Luo, YL Qu, N Wang, L Wang, ZG Han
BMC Genomics, 2017-12-04;18(1):946.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry
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