Selective, high affinity competitive antagonist of the P2Y1
= 2.5 nM; IC50
= 51.6 nM). Fails to block nucleotide signaling at most other P2Y receptors (P2Y2
) and potently inhibits ADP-induced aggregation of human blood platelets in vitro
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Sold under license from the NIH, US Patent 10/169975
2-Substitution of adenine nucleotide analogues containing a bicyclo[3.1.0]hexane ring system locked in a northern conformation: enhanced potency as P2Y1 receptor antagonists.
Kim et al.
Synthesis, biological activity, and molecular modeling of ribose-modified deoxyadenosine bisphosphate analogues as P2Y1 receptor ligands.
Nandanan et al.
2-Chloro N6-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate is a selective high affinity P2Y1 receptor antagonist.
Boyer et al.
The citations listed below are publications that use Tocris products. Selected citations for MRS 2279 include:
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