MRS 2279

Key Product Details

Product Description

MRS 2279 is a selective, high affinity competitive antagonist of the P2Y₁ receptor (K_i = 2.5 nM; IC₅₀ = 51.6 nM). Fails to block nucleotide signaling at most other P2Y receptors (P2Y₂, P2Y₄, P2Y₆, P2Y₁₁ and P2Y₁₂) and potently inhibits ADP-induced aggregation of human blood platelets in vitro (pK_B = 8.05).

Licensing Information

Sold under license from the NIH, US Patent 10/169975

Product Specifications for MRS 2279

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for MRS 2279

The following data is based on the product molecular weight 503.78.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.98 mL	9.92 mL	19.85 mL
5 mM	0.40 mL	1.98 mL	3.97 mL
10 mM	0.20 mL	0.99 mL	1.98 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 40 publications citing the usage of this product.

• Boyer 2-Chloro N⁶-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate is a selective high affinity P2Y₁ receptor antagonist. Br.J.Pharmacol. 2002 PMID: 11959804
• Kim 2-Substitution of adenine nucleotide analogues containing a bicyclo[3.1.0]hexane ring system locked in a northern conformation: enhanced potency as P2Y₁ receptor antagonists. J.Med.Chem 2003 PMID: 14584948
• Nandanan Synthesis, biological activity, and molecular modeling of ribose-modified deoxyadenosine bisphosphate analogues as P2Y₁ receptor ligands. J.Med.Chem. 2000 PMID: 10715151

Product Documents for MRS 2279