MRS 2500 tetraammonium salt

  ( 18 citations )    
Product Datasheet
Catalog Number:2159
Chemical Name:(1R*,2S*)-4-[2-Iodo-6-(methylamino)-9H-purin-9-yl]-2-(phosphonooxy)bicyclo[3.1.0]hexane-1-methanol dihydrogen phosphate ester tetraammonium salt
Product Details
Citations (18)
Supplemental Products
Reviews
Biological Activity
Highly potent and selective antagonist of the platelet P2Y1 receptor (Ki = 0.78 nM). Inhibits ADP-induced aggregation of human platelets with an IC50 value of 0.95 nM. Inhibits the upregulation of NTPDase1 by ATPγS. Prevents thrombus formation in vivo.
Technical Data
  • M.Wt:
    629.29
  • Formula:
    C13H18N5O8P2I.4NH3
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >96
  • Storage:
    Store at -20°C
  • CAS No:
    630103-23-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license from the NIH, US Patent 10/169975
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for MRS 2500 tetraammonium salt include:

18 Citations: Showing 1 - 10
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  1. Paradoxical induction of growth arrest and apoptosis by EGF via the up-regulation of PTEN by activating Redox factor-1/Egr-1 in human lung cancer cells.
    Authors: Ryu Et al.
    Oncotarget  2017;8:4181
  2. The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine.
    Authors: Baron Et al.
    Thromb J  2015;6:e1629
  3. Nucleotide receptors control IL-8/CXCL8 and MCP-1/CCL2 secretions as well as proliferation in human glioma cells.
    Authors: Braganhol Et al.
    Biochim Biophys Acta  2015;1852:120
  4. Analyzing receptor assemblies in the cell membrane using fluorescence anisotropy imaging with TIRF microscopy.
    Authors: Erdélyi Et al.
    PLoS One  2014;9:e100526
  5. Platelet-derived growth factor receptor-α-positive cells and not smooth muscle cells mediate purinergic hyperpolarization in murine colonic muscles.
    Authors: Kurahashi Et al.
    Am J Physiol Cell Physiol  2014;307:C561
  6. The role of P2Y(14) and other P2Y receptors in degranulation of human LAD2 mast cells.
    Authors: Gao Et al.
    J Pharmacol Exp Ther  2013;9:31
  7. Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli.
    Authors: Ilatovskaya Et al.
    Am J Physiol Cell Physiol  2013;305:C1050
  8. Neurogenic mucosal bicarbonate secretion in guinea pig duodenum.
    Authors: Fei Et al.
    Br J Pharmacol  2013;168:880
  9. Antagonism of P2Y1-induced vasorelaxation by acyl CoA: a critical role for palmitate and 3'-phosphate.
    Authors: Alefishat Et al.
    Br J Pharmacol  2013;168:1911
  10. Mechanisms of hemolysis-associated platelet activation.
    Authors: Helms Et al.
    J Thromb Haemost  2013;11:2148
  11. Changes in neuromuscular transmission in the W/W(v) mouse internal anal sphincter.
    Authors: Duffy Et al.
    Neurogastroenterol Motil  2012;24:e41
  12. β-nicotinamide adenine dinucleotide is an enteric inhibitory neurotransmitter in human and nonhuman primate colons.
    Authors: Hwang Et al.
    Gastroenterology  2011;140:608
  13. Endogenous luminal surface adenosine signaling regulates duodenal bicarbonate secretion in rats.
    Authors: Ham Et al.
    J Cell Biochem  2010;335:607
  14. Adenine nucleotide control of coronary blood flow during exercise.
    Authors: Gorman Et al.
    Am J Physiol Heart Circ Physiol  2010;299:H1981
  15. Novel excitatory effects of adenosine triphosphate on contractile and pacemaker activity in rabbit urethral smooth muscle.
    Authors: Bradley Et al.
    J Urol  2010;183:801
  16. Mild hypothermia does not attenuate platelet aggregation and may even increase ADP-stimulated platelet aggregation after clopidogrel treatment.
    Authors: Högberg Et al.
    Purinergic Signal  2009;7:2
  17. PKCalpha regulates platelet granule secretion and thrombus formation in mice.
    Authors: Konopatskaya Et al.
    J Clin Invest  2009;119:399
  18. Evidence for the possible involvement of the P2Y(6) receptor in Ca (2+) mobilization and insulin secretion in mouse pancreatic islets.
    Authors: Ohtani Et al.
    Purinergic Signal  2008;4:365
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