MRS 2500 tetraammonium salt

Key Product Details

Product Description

MRS 2500 tetraammonium salt is a highly potent and selective antagonist of the platelet P2Y₁ receptor (K_i = 0.78 nM). Inhibits ADP-induced aggregation of human platelets with an IC₅₀ value of 0.95 nM. Inhibits the upregulation of NTPDase1 by ATPγS. Prevents thrombus formation in vivo.

Licensing Information

Sold under license from the NIH, US Patent 10/169975

Product Specifications for MRS 2500 tetraammonium salt

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for MRS 2500 tetraammonium salt

The following data is based on the product molecular weight 629.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	7.95 mL	39.73 mL	79.45 mL
1 mM	1.59 mL	7.95 mL	15.89 mL
2 mM	0.79 mL	3.97 mL	7.95 mL
10 mM	0.16 mL	0.79 mL	1.59 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 23 publications citing the usage of this product.

• Lu Stimulation of the P2Y₁ receptor up-regulates nucleoside-triphosphate diphosphohydrolase-1 in human retinal pigment epithelial cells. J.Pharmacol.Exp.Ther. 2007 PMID: 17626796
• Cattaneo Antiaggregatory activity in human platelets of potent antagonists of the P2Y₁ receptor. Biochem.Pharmacol. 2004 PMID: 15476670
• Hechler MRS2500 [2-iodo-N⁶-methyl-(N)-methanocarba-2'-deoxyadenosine-3', 5'-bisphosphate], a potent, selective, and stable antagonist of the platelet P2Y₁ receptor with strong antithrombotic activity in mice. J.Pharmacol.Exp.Ther. 2006 PMID: 16236815
• Kim 2-Substitution of adenine nucleotide analogues containing a bicyclo[3.1.0]hexane ring system locked in a northern conformation: enhanced potency as P2Y₁ receptor antagonists. J.Med.Chem 2003 PMID: 14584948

Product Documents for MRS 2500 tetraammonium salt