MRS 2500 tetraammonium salt

Catalog # Availability Size / Price Qty
2159/1
MRS 2500 tetraammonium salt | CAS No. 630103-23-0 | P2Y Receptor Antagonists
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Description: Highly potent and selective P2Y1 antagonist

Chemical Name: (1R*,2S*)-4-[2-Iodo-6-(methylamino)-9H-purin-9-yl]-2-(phosphonooxy)bicyclo[3.1.0]hexane-1-methanol dihydrogen phosphate ester tetraammonium salt

Purity: ≥96%

Product Details
Citations (20)
Supplemental Products
Reviews

Biological Activity

Highly potent and selective antagonist of the platelet P2Y1 receptor (Ki = 0.78 nM). Inhibits ADP-induced aggregation of human platelets with an IC50 value of 0.95 nM. Inhibits the upregulation of NTPDase1 by ATPγS. Prevents thrombus formation in vivo.

Technical Data

M.Wt:
629.29
Formula:
C13H18N5O8P2I.4NH3
Solubility:
Soluble to 100 mM in water
Purity:
≥96%
Storage:
Store at -20°C
CAS No:
630103-23-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from the NIH, US Patent 10/169975

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Citations for MRS 2500 tetraammonium salt

The citations listed below are publications that use Tocris products. Selected citations for MRS 2500 tetraammonium salt include:

20 Citations: Showing 1 - 10

  1. Connexin-43-dependent ATP release mediates macrophage activation during sepsis.
    Authors: Dosch Et al.
    Elife  2019;8
  2. Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y1 and P2Y12 receptors.
    Authors: Liu Et al.
    Sci Rep  2018;8(1):11380
  3. Paradoxical induction of growth arrest and apoptosis by EGF via the up-regulation of PTEN by activating Redox factor-1/Egr-1 in human lung cancer cells.
    Authors: Ryu Et al.
    Oncotarget  2017;8:4181
  4. The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine.
    Authors: Baron Et al.
    Thromb J  2015;6:e1629
  5. Nucleotide receptors control IL-8/CXCL8 and MCP-1/CCL2 secretions as well as proliferation in human glioma cells.
    Authors: Braganhol Et al.
    Biochim Biophys Acta  2015;1852:120
  6. Analyzing receptor assemblies in the cell membrane using fluorescence anisotropy imaging with TIRF microscopy.
    Authors: Erdélyi Et al.
    PLoS One  2014;9:e100526
  7. Platelet-derived growth factor receptor-α-positive cells and not smooth muscle cells mediate purinergic hyperpolarization in murine colonic muscles.
    Authors: Kurahashi Et al.
    Am J Physiol Cell Physiol  2014;307:C561
  8. The role of P2Y(14) and other P2Y receptors in degranulation of human LAD2 mast cells.
    Authors: Gao Et al.
    J Pharmacol Exp Ther  2013;9:31
  9. Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli.
    Authors: Ilatovskaya Et al.
    Am J Physiol Cell Physiol  2013;305:C1050
  10. Neurogenic mucosal bicarbonate secretion in guinea pig duodenum.
    Authors: Fei Et al.
    Br J Pharmacol  2013;168:880
  11. Antagonism of P2Y1-induced vasorelaxation by acyl CoA: a critical role for palmitate and 3'-phosphate.
    Authors: Alefishat Et al.
    Br J Pharmacol  2013;168:1911
  12. Mechanisms of hemolysis-associated platelet activation.
    Authors: Helms Et al.
    J Thromb Haemost  2013;11:2148
  13. Changes in neuromuscular transmission in the W/W(v) mouse internal anal sphincter.
    Authors: Duffy Et al.
    Neurogastroenterol Motil  2012;24:e41
  14. β-nicotinamide adenine dinucleotide is an enteric inhibitory neurotransmitter in human and nonhuman primate colons.
    Authors: Hwang Et al.
    Gastroenterology  2011;140:608
  15. Endogenous luminal surface adenosine signaling regulates duodenal bicarbonate secretion in rats.
    Authors: Ham Et al.
    J Cell Biochem  2010;335:607
  16. Adenine nucleotide control of coronary blood flow during exercise.
    Authors: Gorman Et al.
    Am J Physiol Heart Circ Physiol  2010;299:H1981
  17. Novel excitatory effects of adenosine triphosphate on contractile and pacemaker activity in rabbit urethral smooth muscle.
    Authors: Bradley Et al.
    J Urol  2010;183:801
  18. Mild hypothermia does not attenuate platelet aggregation and may even increase ADP-stimulated platelet aggregation after clopid. treatment.
    Authors: Högberg Et al.
    Purinergic Signal  2009;7:2
  19. PKCalpha regulates platelet granule secretion and thrombus formation in mice.
    Authors: Konopatskaya Et al.
    J Clin Invest  2009;119:399
  20. Evidence for the possible involvement of the P2Y(6) receptor in Ca (2+) mobilization and Ins secretion in mouse pancreatic islets.
    Authors: Ohtani Et al.
    Purinergic Signal  2008;4:365

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