MRS 2578

  ( 20 citations )    
Product Datasheet
Catalog Number:2146
Chemical Name:N,N''-1,4-Butanediylbis[N'-(3-isothiocyanatophenyl)thiourea
Product Details
Citations (20)
Supplemental Products
Reviews
Biological Activity
Selective antagonist of P2Y6 nucleotide receptors; IC50 values are 37 and 98 nM at human and rat P2Y6 receptors respectively. Displays no activity at P2Y1, P2Y2, P2Y4 and P2Y11 receptors (IC50 > 10 μM). Inhibits agonist-induced cardiomyocyte contraction and UDP-induced phagocytosis.
Technical Data
  • M.Wt:
    472.66
  • Formula:
    C20H20N6S4
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >95
  • Storage:
    Desiccate at -20°C
  • CAS No:
    711019-86-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for MRS 2578 include:

20 Citations: Showing 1 - 10
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  1. Nucleotide receptors control IL-8/CXCL8 and MCP-1/CCL2 secretions as well as proliferation in human glioma cells.
    Authors: Braganhol Et al.
    Biochim Biophys Acta  2015;1852:120
  2. The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate.
    Authors: Nishimura Et al.
    PLoS Pathog  2015;11:e1005184
  3. The PRKAA1/AMPKα1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML.
    Authors: Obba Et al.
    Exp Cell Res  2015;11:1114
  4. Autocrine Regulation of UVA-Induced IL-6 Production via Release of ATP and Activation of P2Y Receptors.
    Authors: Kawano Et al.
    PLoS One  2015;10:e0127919
  5. Enhancement of glucose uptake in mouse skeletal muscle cells and adipocytes by P2Y6 receptor agonists.
    Authors: Balasubramanian Et al.
    Pharmacol Res  2014;9:e116203
  6. Activation of P2Y6 receptors increases the voiding frequency in anaesthetized rats by releasing ATP from the bladder urothelium.
    Authors: Carneiro Et al.
    Br J Pharmacol  2014;171:3404
  7. P2Y6 receptor inhibition perturbs CCL2-evoked signalling in human monocytic and peripheral blood mononuclear cells.
    Authors: Campwala Et al.
    J Cell Sci  2014;127:4964
  8. Microglia P2Y6 receptors mediate nitric oxide release and astrocyte apoptosis.
    Authors: Quintas Et al.
    J Neuroinflammation  2014;11:141
  9. Role of spinal P2Y6 and P2Y11 receptors in neuropathic pain in rats: possible involvement of glial cells.
    Authors: Barragán-Iglesias Et al.
    Mol Pain  2014;10:29
  10. AMP-activated protein kinase as regulator of P2Y(6) receptor-induced insulin secretion in mouse pancreatic β-cells.
    Authors: Balasubramanian Et al.
    PLoS One  2013;85:991
  11. Extracellular UDP enhances P2X-mediated bladder smooth muscle contractility via P2Y(6) activation of the phospholipase C/inositol trisphosphate pathway.
    Authors: Yu Et al.
    FASEB J  2013;27:1895
  12. Investigation of the functional expression of purine and pyrimidine receptors in porcine isolated pancreatic arteries.
    Authors: Alsaqati Et al.
    Purinergic Signal  2013;10:241
  13. Pharmacological characterization of uracil nucleotide-preferring P2Y receptors modulating intestinal motility: a study on mouse ileum.
    Authors: Zizzo Et al.
    Purinergic Signal  2012;8:275
  14. Silencing of P2Y(2) receptors reduces intraocular pressure in New Zealand rabbits.
    Authors: Martín-Gil Et al.
    Br J Pharmacol  2012;165:1163
  15. Purinergic signaling is required for fluid shear stress-induced NF-κB translocation in osteoblasts.
    Authors: Genetos Et al.
    Biochem Pharmacol  2011;317:737
  16. Selective induction of endothelial P2Y6 nucleotide receptor promotes vascular inflammation.
    Authors: Riegel Et al.
    Blood  2011;117:2548
  17. Involvement of SLC17A9-dependent vesicular exocytosis in the mechanism of ATP release during T cell activation.
    Authors: Tokunaga Et al.
    J Biol Chem  2010;285:17406
  18. Characterization of P2Y receptor subtypes functionally expressed on neonatal rat cardiac myofibroblasts.
    Authors: Talasila Et al.
    Br J Pharmacol  2009;158:339
  19. Attenuation of apoptosis in vitro and ischemia/reperfusion injury in vivo in mouse skeletal muscle by P2Y6 receptor activation.
    Authors: Mamedova Et al.
    Transl Oncol  2008;58:232
  20. Extracellular nucleotides mediate LPS-induced neutrophil migration in vitro and in vivo.
    Authors: Kukulski Et al.
    Autophagy  2007;81:1269
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