Selective antagonist of P2Y6
nucleotide receptors; IC50
values are 37 and 98 nM at human and rat P2Y6
receptors respectively. Displays no activity at P2Y1
> 10 μ
M). Inhibits agonist-induced cardiomyocyte contraction and UDP-induced phagocytosis.
Soluble to 50 mM in DMSO
Desiccate at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Diisothiocyanate derivatives as potent, insurmountable antagonists of P2Y6 nucleotide receptors.
Mamedova et al.
UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis.
Koizumi et al.
Extracellular nucleotides mediate LPS-induced neutrophil migration in vitro and in vivo.
Kukulski et al.
The citations listed below are publications that use Tocris products. Selected citations for MRS 2578 include:
Showing Results 1 - 10 of 16