MRS 2693 trisodium salt
Chemical Name: 5-Iodouridine-5'-O-diphosphate trisodium salt
Biological ActivitySelective P2Y6 agonist (EC50 = 0.015 μM at the hP2Y6 receptor). Displays no activity at other P2Y subtypes. Exerts a cytoprotective effect in an in vivo mouse model of hindlimb skeletal muscle ischemia/reperfusion injury.
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Structure-activity relationships of uridine 5'-diphosphate analogues at the human P2Y6 receptor.
Besada et al.
Attenuation of apoptosis in vitro and ischemia/reperfusion injury in vivo in mouse skeletal muscle by P2Y6 receptor activation.
Mamedova et al.
Development of selective agonists and antagonists of P2Y receptors.
Jacobson et al.
Citations for MRS 2693 trisodium salt
The citations listed below are publications that use Tocris products. Selected citations for MRS 2693 trisodium salt include:
4 Citations: Showing 1 - 4
The PRKAA1/AMPKα1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML.
Authors: Obba Et al.
Pyrimidinergic Receptor Activation Controls Toxoplasma gondii Infection in Macrophages.
Authors: Moreira-Souza Et al.
PLoS One 2015;10:e0133502
Extracellular UDP enhances P2X-mediated bladder smooth muscle contractility via P2Y(6) activation of the phospholipase C/inositol trisphosphate pathway.
Authors: Yu Et al.
FASEB J 2013;27:1895
Uridine adenosine tetraphosphate-induced contraction is increased in renal but not pulmonary arteries from DOCA-salt hypertensive rats.
Authors: Matsumoto Et al.
Am J Physiol Heart Circ Physiol 2011;301:H409
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