MRS 2693 trisodium salt

Catalog # Availability Size / Price Qty
2502/1
MRS 2693 trisodium salt | CAS No. 1448858-83-0 | P2Y Receptor Agonists
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Description: Selective P2Y6 agonist
Alternative Names: 5-Iodo-UDP trisodium salt

Chemical Name: 5-Iodouridine-5'-O-diphosphate trisodium salt

Purity: ≥95%

Product Details
Citations (4)
Supplemental Products
Reviews (1)

Biological Activity

MRS 2693 trisodium salt is a selective P2Y6 agonist (EC50 = 0.015 μM at the hP2Y6 receptor). Displays no activity at other P2Y subtypes. Exerts a cytoprotective effect in an in vivo mouse model of hindlimb skeletal muscle ischemia/reperfusion injury.

Technical Data

M.Wt:
596
Formula:
C9H10IN2Na3O12P2
Solubility:
Soluble in water (supplied pre-dissolved at a concentration of 10mM)
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
1448858-83-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Structure-activity relationships of uridine 5'-diphosphate analogues at the human P2Y6 receptor.
    Besada et al.
    J.Med.Chem., 2006;49:5532
  2. Attenuation of apoptosis in vitro and ischemia/reperfusion injury in vivo in mouse skeletal muscle by P2Y6 receptor activation.
    Mamedova et al.
    Pharmacol.Res., 2008;58:232
  3. Development of selective agonists and antagonists of P2Y receptors.
    Jacobson et al.
    Purinerg.Sig., 2009;5:75

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Citations for MRS 2693 trisodium salt

The citations listed below are publications that use Tocris products. Selected citations for MRS 2693 trisodium salt include:

4 Citations: Showing 1 - 4

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Good product
By Anonymous on 09/09/2021
Application: Species: Human

Used MRS 2693 in a fluorescence-based intracellular calcium assay, and the agonist came pre-dissolved in water to a concentration of 10 mM.


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