MTEP hydrochloride

Key Product Details

Product Description

MTEP hydrochloride is a potent, selective and non-competitive mGlu₅ antagonist (IC₅₀ = 5 nM in Ca²⁺-flux assay; K_i= 16 nM). Displays anxiolytic activity in vivo and is orally active.

Licensing Information

Manufactured and sold under license from Merck & Co., Inc. for use solely for preclinical research purposes (ie: not for administration to or other use in humans)

Product Specifications for MTEP hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for MTEP hydrochloride

The following data is based on the product molecular weight 236.72.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

5 4 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.22 mL	21.12 mL	42.24 mL
5 mM	0.84 mL	4.22 mL	8.45 mL
10 mM	0.42 mL	2.11 mL	4.22 mL
50 mM	0.08 mL	0.42 mL	0.84 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 36 publications citing the usage of this product.

• Brodkin Reduced stress-induced hyperthermia in mGluR5 knockout mice. Eur.J.Neurosci. 2002 PMID: 12473093
• Cosford 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]- pyridine: A potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity. J.Med.Chem. 2003 PMID: 12519057
• Roppe 5-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-2,3'-bipyridine: a highly potent, orally active metabotropic glutamate subtype 5 (mGlu5) receptor antagonist with anxiolytic activity. Bioorg.Med.Chem.Lett. 2004 PMID: 15225713
• Klodzinska Anxiolytic-like effects of MTEP, a potent and selective mGlu5 receptor agonist does not involve GABA_A signaling. Neuropharmacology 2004 PMID: 15275823
• Bradbury Metabotropic glutamate receptor mGlu5 is a mediator of appetite and energy balance in rats and mice. J.Pharmacol.Exp.Ther. 2005 PMID: 15590770

Product Documents for MTEP hydrochloride