MTEP hydrochloride

Catalog # Availability Size / Price Qty
2921/10
2921/50
MTEP hydrochloride | CAS No. 1186195-60-7 | Group I mGluR Antagonists
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Description: Potent and selective mGlu5 antagonist

Chemical Name: 3-((2-Methyl-1,3-thiazol-4-yl)ethynyl)pyridine hydrochloride

Purity: ≥99%

Product Details
Citations (11)
Supplemental Products
Reviews

Biological Activity

MTEP hydrochloride is a potent, selective and non-competitive mGlu5 antagonist (IC50 = 5 nM in Ca2+-flux assay; Ki= 16 nM). Displays anxiolytic activity in vivo and is orally active.

Technical Data

M.Wt:
236.72
Formula:
C11H8N2S.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
1186195-60-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Manufactured and sold under license from Merck & Co., Inc. for use solely for preclinical research purposes (ie: not for administration to or other use in humans)

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Citations for MTEP hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for MTEP hydrochloride include:

11 Citations: Showing 1 - 10

  1. Neuronal Activity-Dependent Activation of Astroglial Calcineurin in Mouse Primary Hippocampal Cultures.
    Authors: Lim Et al.
    Int J Mol Sci  2018;19
  2. Cell-Type-Specific Translation Profiling Reveals a Novel Strategy for Treating Fragile X Syndrome.
    Authors: Thomson Et al.
    Neuron  2017;95:550
  3. The metabotropic glutamate receptor 5 role on motor behavior involves specific neural substrates.
    Authors: Guimaraes Et al.
    Cell Death Dis  2015;8:24
  4. Neuron-glia signaling in developing retina mediated by neurotransmitter spillover.
    Authors: Rosa Et al.
    Mol Brain  2015;4
  5. Glutamate transporter GLT-1 mediates N-acetylcysteine inhibition of cocaine reinstatement.
    Authors: Reissner Et al.
    Elife  2015;20:316
  6. Loss of Metabotropic Glutamate Receptor 5 Function on Peripheral Benzodiazepine Receptor in Mice Prenatally Exposed to LPS.
    Authors: Arsenault Et al.
    PLoS One  2015;10:e0142093
  7. Modulation of neuronal microcircuit activities within the medial prefrontal cortex by mGluR5 positive allosteric modulator.
    Authors: Pollard Et al.
    J Psychopharmacol  2014;28:935
  8. Optogenetic stimulation of the corticothalamic pathway affects relay cells and GABAergic neurons differently in the mouse visual thalamus.
    Authors: Jurgens Et al.
    PLoS One  2012;7:e45717
  9. Intrathecal injection of metabotropic glutamate receptor subtype 3 and 5 agonist/antagonist attenuates bone cancer pain by inhibition of spinal astrocyte activation in a mouse model.
    Authors: Ren Et al.
    Anesthesiology  2012;116:122
  10. Reversible gating of endocannabinoid plasticity in the amygdala by chronic stress: a potential role for monoacylglycerol lipase inhibition in the prevention of stress-induced behavioral adaptation.
    Authors: Sumislawski Et al.
    Neuropsychopharmacology  2011;36:2750

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