MTEP hydrochloride

  ( 9 citations )    
Product Datasheet
Catalog Number:2921
Chemical Name:3-((2-Methyl-1,3-thiazol-4-yl)ethynyl)pyridine hydrochloride
Product Details
Citations (9)
Supplemental Products
Reviews
Biological Activity
Potent, selective and non-competitive mGlu5 antagonist (IC50 = 5 nM in Ca2+-flux assay; Ki= 16 nM). Displays anxiolytic activity in vivo and is orally active.
Technical Data
  • M.Wt:
    236.72
  • Formula:
    C11H8N2S.HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at -20°C
  • CAS No:
    1186195-60-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Manufactured and sold under license from Merck & Co., Inc. for use solely for preclinical research purposes (ie: not for administration to or other use in humans)
Product Datasheets
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for MTEP hydrochloride include:

9 Citations: Showing 1 - 9
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  1. Cell-Type-Specific Translation Profiling Reveals a Novel Strategy for Treating Fragile X Syndrome.
    Authors: Thomson Et al.
    Neuron  2017;95:550
  2. The metabotropic glutamate receptor 5 role on motor behavior involves specific neural substrates.
    Authors: Guimaraes Et al.
    Cell Death Dis  2015;8:24
  3. Neuron-glia signaling in developing retina mediated by neurotransmitter spillover.
    Authors: Rosa Et al.
    Mol Brain  2015;4
  4. Glutamate transporter GLT-1 mediates N-acetylcysteine inhibition of cocaine reinstatement.
    Authors: Reissner Et al.
    Elife  2015;20:316
  5. Loss of Metabotropic Glutamate Receptor 5 Function on Peripheral Benzodiazepine Receptor in Mice Prenatally Exposed to LPS.
    Authors: Arsenault Et al.
    PLoS One  2015;10:e0142093
  6. Modulation of neuronal microcircuit activities within the medial prefrontal cortex by mGluR5 positive allosteric modulator.
    Authors: Pollard Et al.
    J Psychopharmacol  2014;28:935
  7. Optogenetic stimulation of the corticothalamic pathway affects relay cells and GABAergic neurons differently in the mouse visual thalamus.
    Authors: Jurgens Et al.
    PLoS One  2012;7:e45717
  8. Reversible gating of endocannabinoid plasticity in the amygdala by chronic stress: a potential role for monoacylglycerol lipase inhibition in the prevention of stress-induced behavioral adaptation.
    Authors: Sumislawski Et al.
    Neuropsychopharmacology  2011;36:2750
  9. Metabotropic glutamate receptor 5/Homer interactions underlie stress effects on fear.
    Authors: Tronson Et al.
    Addict Biol  2010;68:1007

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