Mucolipin 1 Antibody [DyLight 405]

Novus Biologicals | Catalog # NB110-82375V

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Predicted:

Monkey (90%). Backed by our 100% Guarantee.

Applications

Western Blot

Label

DyLight 405 (Excitation = 400 nm, Emission = 420 nm)

Antibody Source

Polyclonal Rabbit IgG
View all Mucolipin 1 Primary Antibodies »

Product Specifications

Immunogen

Synthetic peptide made to a C-terminal portion of mouse Mucolipin 1 (within residues 500-580). [Swiss-Prot# Q99J21]

Reactivity Notes

Use in Mouse reported in scientific literature (PMID:34964698).

Localization

Cell membrane; Multi-pass membrane protein.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Applications for Mucolipin 1 Antibody [DyLight 405]

Application
Recommended Usage

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: Mucolipin 1

Mucolipin 1 (MCOLN1, mucolipidin or TRPML1), is a member of TRP ion channels family and unlike most TRPs, mucolipin 1 primarily resides in the membranes of endocytic pathway (late endosomes/lysosomes). Widely expressed as multipass membrane protein, mucolipin 1's high expression levels are found in brain, liver and kidney. Mucolipin 1 activation by phosphatidylinositol 3,5-bisphosphate [PtdIns(3,5)P(2)], which is predominantly found in endocytic pathway and mucolipin 1 regulates the fusion/fission of endocytic pathway vesicles, and/or some aspect of lysosomal ion homeostasis such as pH, iron, or zinc content. It is a cation channel, and besides controlling membrane trafficking of proteins and lipids, it plays a major role in Ca2+ transport regulating lysosomal exocytosis. MCOLN1 mutation mediated mucolipin 1 down-regulation results in rare lysosomal storage disease mucolipidosis type IV (MLIV) that is characterized by progressive neurodegeneration with early onset, mental retardation, corneal opacity, retinal degeneration, vacuolization of parietal cells, constitutive achlorhydria and an elevated gastrin levels.

Long Name

Mucolipin-1

Alternate Names

MCOLN1, MG-2, ML1, ML4, MSTP080, Mucolipidin, TRPML1

Gene Symbol

MCOLN1

Additional Mucolipin 1 Products

Product Documents for Mucolipin 1 Antibody [DyLight 405]

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for Mucolipin 1 Antibody [DyLight 405]



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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