Mycophenolate mofetil

Key Product Details

Product Description

Mycophenolate mofetil is an immunosuppressant prodrug of mycophenolic acid (MPA) (Cat. No. 1505). Hydrolyzed by esterases to release MPA, a reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH). Used to prevent organ rejection after transplantation. Displays inhibitory activity of lymphocyte functions. Inhibits type 1 collagen expression, enhances MMP-1 expression, and reduces α-smooth muscle actin gene expression.

Product Specifications for Mycophenolate mofetil

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Mycophenolate mofetil

The following data is based on the product molecular weight 433.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.31 mL	11.53 mL	23.07 mL
5 mM	0.46 mL	2.31 mL	4.61 mL
10 mM	0.23 mL	1.15 mL	2.31 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Roos In vitro evidence for a direct antifibrotic role of the immunosuppressive drug mycophen. mofetil. J.Pharm.Exp.Ther.
• Allison and Eugui Purine metabolism and immunosuppressive effects of mycophen. mofetil (MMF). Clin.Transplant. 1996 PMID: 8680053

Product Documents for Mycophenolate mofetil