Catalog Number: 4102
Chemical Name: 6-(1,3-Dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic acid 2-(4-morpholinyl)ethyl ester
Biological Activity
Immunosuppressant prodrug of mycophenolic acid (MPA) (Cat. No. 1505). Hydrolyzed by esterases to release MPA (a reversible inhibitor of inosine monophosphate dehydrogenase). Used to prevent organ rejection after transplantation. Displays inhibitory activity of lymphocyte functions. Inhibits type 1 collagen expression, enhances MMP-1 expression, and reduces α-smooth muscle actin gene expression.
Technical Data
  • M.Wt:
    433.49
  • Formula:
    C23H31NO7
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    128794-94-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Purine metabolism and immunosuppressive effects of mycophenolate mofetil (MMF).
    Allison and Eugui
    Clin.Transplant., 1996;10:77
  2. In vitro evidence for a direct antifibrotic role of the immunosuppressive drug mycophenolate mofetil.
    Roos et al.
    J.Pharm.Exp.Ther., 2007;321:583

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