Catalog Number: 1505
Chemical Name: 6-(1,3-Dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic acid
Biological Activity
Immunosuppressive agent with antiviral and antitumor effects in vitro and in vivo. Potently inhibits inosine monophosphate dehydrogenase, thus inhibiting de novo GTP synthesis leading to decreased RNA and DNA synthesis. Reversibly inhibits proliferation of T and B lymphocytes and antibody formation.
Technical Data
  • M.Wt:
    320.34
  • Formula:
    C17H20O6
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    24280-93-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Mechanisms of action of mycophenolic acid.
    Allison et al.
    Ann.N.Y.Acad.Sci., 1993;696:63
  2. Distinct inhibitory effects of spinal endomorphin-1 and endomorphin-2 on evoked dorsal horn neuronal responses in the rat.
    Chapman et al.
    Br.J.Pharmacol., 1997;122:1537
  3. Pharmacological characterization of endomorphin-1 and endomorphin-2 in mouse brain.
    Goldberg et al.
    J.Pharmacol.Exp.Ther., 1998;286:1007
  4. Lymphocyte-selective cytostatic and immunosuppressive effects of mycophenolic acid in vitro: role of deoxyguanosine nucleotide depeletion.
    Eugui et al.
    Scand.J.Immunol., 1991;33:161
  5. Mycophenolic acid, an inhibitor of IMP dehydrogenase that is also an immunosuppressive agent, suppresses the cytokine-induced nitric oxide production in mouse and rat vascular endothelial cells.
    Senda et al.
    Transplantation, 1995;60:1143
  6. A potent and selective endogenous agonist for the μ-opiate receptor.
    Zadina et al.
    Nature, 1997;386:499
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Mycophenolic acid include:

1 Citations: Showing 1 - 1

  1. Neurogenin 3 Expressing Cells in the Human Exocrine Pancreas Have the Capacity for Endocrine Cell Fate.
    Authors: Gomez Et al.
    PLoS One 2015;10:e0133862

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