Immunosuppressive agent with antiviral and antitumor effects in vitro
and in vivo
. Potently inhibits inosine monophosphate dehydrogenase, thus inhibiting de novo GTP synthesis leading to decreased RNA and DNA synthesis. Reversibly inhibits proliferation of T and B lymphocytes and antibody formation.
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Mechanisms of action of mycophenolic acid.
Allison et al.
Distinct inhibitory effects of spinal endomorphin-1 and endomorphin-2 on evoked dorsal horn neuronal responses in the rat.
Chapman et al.
Pharmacological characterization of endomorphin-1 and endomorphin-2 in mouse brain.
Goldberg et al.
Lymphocyte-selective cytostatic and immunosuppressive effects of mycophenolic acid in vitro: role of deoxyguanosine nucleotide depeletion.
Eugui et al.
Mycophenolic acid, an inhibitor of IMP dehydrogenase that is also an immunosuppressive agent, suppresses the cytokine-induced nitric oxide production in mouse and rat vascular endothelial cells.
Senda et al.
A potent and selective endogenous agonist for the μ-opiate receptor.
Zadina et al.
The citations listed below are publications that use Tocris products. Selected citations for Mycophenolic acid include:
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