NCX 4040

Catalog # Availability Size / Price Qty
4531/10
4531/50
NCX 4040 | CAS No. 287118-97-2 | Cyclooxygenase Inhibitors
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Description: NO-donating aspirin; anti-inflammatory and antitumor

Chemical Name: 2-(Acetyloxy)benzoic acid 4-[(nitrooxy)methyl]phenyl ester

Purity: ≥98%

Product Details
Reviews

Biological Activity

NO-donating aspirin; anti-inflammatory. Blocks inflammatory mediator production in isolated human monocytes (IC50 values are 0.07, 0.13, 0.15 and 0.18 μM for IL-1β, PGE2, IL-10 and TNF-α respectively). Decreases COX-2 expression (IC50 = 0.13 μM); disrupts proteasome-mediated degradation of iκB-α. Antiproliferative in HCT116 colon cancer cells; sensitizes drug-resistant ovarian tumor cells to cisplatin (Cat. No. 2251).

Technical Data

M.Wt:
331.28
Formula:
C16H13NO7
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
287118-97-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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