Catalog Number: 1240
Chemical Name: 8,8'-[carbonylbis(imino-3,1-phenylenecarbonylimino)]bis-1,3,5-naphthalene-trisulphonic acid, hexasodium salt
Biological Activity
A subtype-selective, competitive and reversible P2X1 receptor antagonist. Displays IC50 values of 0.21, 28.9, > 50 and > 100 μM for human P2X1, P2X3, P2X2, and P2X4-mediated responses respectively. Selective over adrenoceptors, histamine and P2Y receptors. Also selectively inhibits the α-subunit of Go/i (EC50 ~300 nM).
Technical Data
  • M.Wt:
    1162.86
  • Formula:
    C35H20N4Na6O21S6
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Desiccate at RT
  • CAS No:
    104869-31-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Suramin analogues as subtype-selective G protein inhibitors.
    Freissmuth et al.
    Mol.Pharmacol., 1996;49:602
  2. The effect of P2 receptor antagonists and ATPase inhibition on sympathetic purinergic neurotransmission in the guinea-pig isolated vas deferens.
    Sneddon et al.
    Br.J.Pharmacol., 2000;129:1089
  3. Antagonistic properties of the suramin analogue NF023 at heterologously expressed P2X receptors.
    Soto et al.
    Neuropharmacology, 1999;38:141
  4. Novel competitive antagonists for P2 purinoceptors.
    Van Rhee et al.
    Eur.J.Pharmacol., 1994;268:1
Citations:

The citations listed below are publications that use Tocris products. Selected citations for NF 023 include:

5 Citations: Showing 1 - 5
Filter your results:

  1. The approved pediatric drug suramin identified as a clinical candidate for the treatment of EV71 infection-suramin inhibits EV71 infection in vitro and in vivo.
    Authors: Ren Et al.
    Emerg Microbes Infect 2014;3:e62
  2. Acid ceramidase induces sphingosine kinase 1/S1P receptor 2-mediated activation of oncogenic Akt signaling.
    Authors: Beckham Et al.
    Oncogenesis 2013;2:e49
  3. ATP release and autocrine signaling through P2X4 receptors regulate γδ T cell activation.
    Authors: Manohar Et al.
    J Leukoc Biol 2012;92:787
  4. Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors.
    Authors: Donnelly-Roberts Et al.
    Br J Pharmacol 2009;157:1203
  5. Localization and function of ATP and GABAA receptors expressed by nociceptors and other postnatal sensory neurons in rat.
    Authors: Labrakakis Et al.
    J Physiol 2003;549:131

Have you used NF 023?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

Feedback

Customer Information