Catalog Number: 2450
Chemical Name: 8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-fluoro-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic acid hexasodium salt
Biological Activity
Purinergic receptor antagonist that potently inhibits P2Y11 receptor activity (IC50 = 463 nM). Displays selectivity for P2Y11 and P2X1 receptors over P2Y1, P2Y2, P2X2, P2X3, P2X4 and P2X7 receptors. Inhibits NAD+-induced activation of human granulocytes.
Technical Data
  • M.Wt:
    1437.08
  • Formula:
    C49H28F2N6Na6O23S6
  • Solubility:
    Soluble to 50 mM in water
  • Storage:
    Desiccate at RT
  • CAS No:
    104869-26-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Synthesis and structure-activity relationships of suramin-derived P2Y11 receptor antagonists with nanomolar potency.
    Ullmann et al.
    J.Med.Chem., 2005;48:7040
  2. Extracellular NAD+ is an agonist of the human P2Y11 purinergic receptor in human granulocytes.
    Moreschi et al.
    J.Biol.Chem., 2006;281:31419
Citations:

The citations listed below are publications that use Tocris products. Selected citations for NF 157 include:

6 Citations: Showing 1 - 6
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  1. Activation of P2X7 and P2Y11 purinergic receptors inhibits migration and normalizes tumor-derived endothelial cells via cAMP signaling
    Authors: Avanzato Et al.
    Scientific Reports 2016;6:32602
  2. Autocrine Regulation of UVA-Induced IL-6 Production via Release of ATP and Activation of P2Y Receptors.
    Authors: Kawano Et al.
    PLoS One 2015;10:e0127919
  3. The approved pediatric drug suramin identified as a clinical candidate for the treatment of EV71 infection-suramin inhibits EV71 infection in vitro and in vivo.
    Authors: Ren Et al.
    Emerg Microbes Infect 2014;3:e62
  4. ATP release and autocrine signaling through P2X4 receptors regulate γδ T cell activation.
    Authors: Manohar Et al.
    J Leukoc Biol 2012;92:787
  5. Increase of intracellular Ca2+ by purinergic receptors in cultured rat lacrimal gland myoepithelial cells.
    Authors: Ohtomo Et al.
    Invest Ophthalmol Vis Sci 2011;52:9503
  6. Characterization of P2Y receptor subtypes functionally expressed on neonatal rat cardiac myofibroblasts.
    Authors: Talasila Et al.
    Br J Pharmacol 2009;158:339

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