Chemical Name: 8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-fluoro-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic acid hexasodium salt
Biological ActivityPurinergic receptor antagonist that potently inhibits P2Y11 receptor activity (IC50 = 463 nM). Displays selectivity for P2Y11 and P2X1 receptors over P2Y1, P2Y2, P2X2, P2X3, P2X4 and P2X7 receptors. Inhibits NAD+-induced activation of human granulocytes.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Synthesis and structure-activity relationships of suramin-derived P2Y11 receptor antagonists with nanomolar potency.
Ullmann et al.
Extracellular NAD+ is an agonist of the human P2Y11 purinergic receptor in human granulocytes.
Moreschi et al.
Citations for NF 157
The citations listed below are publications that use Tocris products. Selected citations for NF 157 include:
12 Citations: Showing 1 - 10
Connexin-43-dependent ATP release mediates macrophage activation during sepsis.
Authors: Dosch Et al.
Antagonism of P2Y11 receptor (P2Y11R) protects epidermal stem cells against UV-B irradiation.
Authors: Wu Et al.
Am J Transl Res 2019;11:4738
Anti-Depressant Flu Reveals its Therapeutic Effect Via Astrocytes.
Authors: Kinoshita Et al.
Activation of P2X7 and P2Y11 purinergic receptors inhibits migration and normalizes tumor-derived endothelial cells via cAMP signaling
Authors: Avanzato Et al.
Scientific Reports 2016;6:32602
Mitochondrial Dysfunction, Depleted Purinergic Signaling, and Defective T Cell Vigilance and Immune Defense.
Authors: Ledderose Et al.
J Infect Dis 2016;213:456
Nucleotide receptors control IL-8/CXCL8 and MCP-1/CCL2 secretions as well as proliferation in human glioma cells.
Authors: Braganhol Et al.
Biochim Biophys Acta 2015;1852:120
The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate.
Authors: Nishimura Et al.
PLoS Pathog 2015;11:e1005184
Autocrine Regulation of UVA-Induced IL-6 Production via Release of ATP and Activation of P2Y Receptors.
Authors: Kawano Et al.
PLoS One 2015;10:e0127919
The approved pediatric drug suramin identified as a clinical candidate for the treatment of EV71 infection-suramin inhibits EV71 infection in vitro and in vivo.
Authors: Ren Et al.
Emerg Microbes Infect 2014;3:e62
ATP release and autocrine signaling through P2X4 receptors regulate γδ T cell activation.
Authors: Manohar Et al.
J Leukoc Biol 2012;92:787
Increase of intracellular Ca2+ by purinergic receptors in cultured rat lacrimal gland myoepithelial cells.
Authors: Ohtomo Et al.
Invest Ophthalmol Vis Sci 2011;52:9503
Characterization of P2Y receptor subtypes functionally expressed on neonatal rat cardiac myofibroblasts.
Authors: Talasila Et al.
Br J Pharmacol 2009;158:339
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