NF 157

  ( 8 citations )    
Product Datasheet
Catalog Number:2450
Chemical Name:8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-fluoro-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic acid hexasodium salt
Product Details
Citations (8)
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Reviews
Biological Activity
Purinergic receptor antagonist that potently inhibits P2Y11 receptor activity (IC50 = 463 nM). Displays selectivity for P2Y11 and P2X1 receptors over P2Y1, P2Y2, P2X2, P2X3, P2X4 and P2X7 receptors. Inhibits NAD+-induced activation of human granulocytes.
Technical Data
  • M.Wt:
    1437.08
  • Formula:
    C49H28F2N6Na6O23S6
  • Solubility:
    Soluble to 50 mM in water
  • Storage:
    Desiccate at RT
  • CAS No:
    104869-26-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for NF 157 include:

8 Citations: Showing 1 - 8
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  1. Activation of P2X7 and P2Y11 purinergic receptors inhibits migration and normalizes tumor-derived endothelial cells via cAMP signaling
    Authors: Avanzato Et al.
    Scientific Reports  2016;6:32602
  2. Nucleotide receptors control IL-8/CXCL8 and MCP-1/CCL2 secretions as well as proliferation in human glioma cells.
    Authors: Braganhol Et al.
    Biochim Biophys Acta  2015;1852:120
  3. The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate.
    Authors: Nishimura Et al.
    PLoS Pathog  2015;11:e1005184
  4. Autocrine Regulation of UVA-Induced IL-6 Production via Release of ATP and Activation of P2Y Receptors.
    Authors: Kawano Et al.
    PLoS One  2015;10:e0127919
  5. The approved pediatric drug suramin identified as a clinical candidate for the treatment of EV71 infection-suramin inhibits EV71 infection in vitro and in vivo.
    Authors: Ren Et al.
    Emerg Microbes Infect  2014;3:e62
  6. ATP release and autocrine signaling through P2X4 receptors regulate γδ T cell activation.
    Authors: Manohar Et al.
    J Leukoc Biol  2012;92:787
  7. Increase of intracellular Ca2+ by purinergic receptors in cultured rat lacrimal gland myoepithelial cells.
    Authors: Ohtomo Et al.
    Invest Ophthalmol Vis Sci  2011;52:9503
  8. Characterization of P2Y receptor subtypes functionally expressed on neonatal rat cardiac myofibroblasts.
    Authors: Talasila Et al.
    Br J Pharmacol  2009;158:339

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