Purinergic receptor antagonist that potently inhibits P2Y11
receptor activity (IC50
= 463 nM). Displays selectivity for P2Y11
receptors over P2Y1
receptors. Inhibits NAD+
-induced activation of human granulocytes.
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All Tocris products are intended for laboratory research use only.
Synthesis and structure-activity relationships of suramin-derived P2Y11 receptor antagonists with nanomolar potency.
Ullmann et al.
Extracellular NAD+ is an agonist of the human P2Y11 purinergic receptor in human granulocytes.
Moreschi et al.
The citations listed below are publications that use Tocris products. Selected citations for NF 157 include:
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