NF 546

Tocris Bioscience | Catalog # 3892

Selective P2Y11 agonist
Tocris Bioscience

Key Product Details

Description

Selective P2Y11 agonist
View all P2Y Receptor Agonists »

Product Description

NF 546 is a P2Y11 agonist (pEC50 = 6.27). Exhibits selectivity for P2Y11 over a range of P2Y and P2X receptors. Also inhibits DNA-binding activity of HMGA2 (IC50 = 5.49 μM).

Product Specifications for NF 546

Molecular Weight

1180.74

Formula

C47H44N6Na4O17P4

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

4,4'-(Carbonylbis(imino-3,1-phenylene-carbonylimino-3,1-(4-methyl-phenylene)carbonylimino))-bis(1,3-xylene-alpha,alpha'-diphosphonic acid tetrasodium salt

CAS Number

1006028-37-0

PubChem ID

73755075

InChI Key

GSMUPMANKNAMAS-UHFFFAOYSA-J

SMILES

[Na+].[Na+].[Na+].[Na+].CC1=CC=C(C=C1NC(=O)C1=CC=CC(NC(=O)NC2=CC=CC(=C2)C(=O)NC2=C(C)C=CC(=C2)C(=O)NC2=CC=C(CP(O)([O-])=O)C=C2CP(O)([O-])=O)=C1)C(=O)NC1=C(CP(O)([O-])=O)C=C(CP(O)([O-])=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 11.81 10 with gentle warming

Preparing Stock Solutions for NF 546

The following data is based on the product molecular weight 1180.74.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 8.47 mL 42.35 mL 84.69 mL
0.5 mM 1.69 mL 8.47 mL 16.94 mL
1 mM 0.85 mL 4.23 mL 8.47 mL
5 mM 0.17 mL 0.85 mL 1.69 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 22 publications citing the usage of this product.

Product Documents for NF 546

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for NF 546

For research use only

Related Research Areas

Bioactive Lipids and Receptors

Customer Reviews for NF 546 (1)

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  • Cell growth regulator
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: H69
    Verified Customer | Posted 06/10/2019
    Used this compound in various concentrations (5-30 uM) to check the cell growth in H69 cells by InCucyte.
    NF 546 3892

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