Catalog Number: 3892
Chemical Name: 4,4'-(Carbonylbis(imino-3,1-phenylene-carbonylimino-3,1-(4-methyl-phenylene)carbonylimino))-bis(1,3-xylene-alpha,alpha'-diphosphonic acid tetrasodium salt
Biological Activity
P2Y11 agonist (pEC50 = 6.27). Exhibits selectivity for P2Y11 over a range of P2Y and P2X receptors.
Technical Data
  • M.Wt:
    1180.74
  • Formula:
    C47H44N6Na4O17P4
  • Solubility:
    Soluble to 10 mM in water with gentle warming
  • Purity:
    >95%
  • Storage:
    Store at -20°C
  • CAS No:
    1006028-37-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. NF546 [4,4'-(carbonylbis(imino-3,1-phenylene-carbonylimino-3,1-(4-methyl-phenylene)-carbonylimino))-bis(1,3-xylene-γ,γ'-diphosphonic acid) tetrasodium salt] is a non-nucleotide P2Y11 agonist and stimulates release of interleuk
    Meis et al.
    J.Pharmacol.Exp.Ther., 2010;332:238
Citations:

The citations listed below are publications that use Tocris products. Selected citations for NF 546 include:

2 Citations: Showing 1 - 2
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  1. Role of spinal P2Y6 and P2Y11 receptors in neuropathic pain in rats: possible involvement of glial cells.
    Authors: Barragán-Iglesias Et al.
    Mol Pain 2014;10:29
  2. The role of P2Y(14) and other P2Y receptors in degranulation of human LAD2 mast cells.
    Authors: Gao Et al.
    Sci Adv 2013;9:31

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