Eukaryotic elongation factor 2 (eEF-2) kinase (CaMK III) inhibitor (IC50
= 60 nM) that displays 125-fold, > 1300-fold and > 1500-fold selectivity over PKC, PKA and CaMK II respectively. Decreases the viability of a variety of cancer cell lines (IC50
values are 0.7 - 4.8 μ
M) and blocks G1
/S cell cycle progression. Shown to induce eEF-2 phosphorylation in cancer cells. Also an effective antibacterial agent; inhibits histidine protein kinase in vitro
= 6.6 μ
M) and in vivo
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) induces phosphorylation of eukaryotic elongation factor-2 (eEF2): a cautionary note on the anticancer mechanism of an eEF2 kinase inhibitor.
Identification and characterization of an inhibitor of eukaryotic elongation factor 2 kinase against human cancer cell lines.
Arora et al.
Cancer Res., 2003;63:6894
P-glycoprotein mediates resistance to histidine kinase inhibitors.
Arora et al.
Antibacterial agents that inhibit histidine protein kinase YycG of Bacillus subtilis.
Yamamoto et al.
The citations listed below are publications that use Tocris products. Selected citations for NH 125 include:
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