NH 125

Catalog # Availability Size / Price Qty
3439/10
3439/50
NH 125 | CAS No. 278603-08-0 | CaM Kinase Inhibitors
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Description: CaM kinase III (eEF-2 kinase) inhibitor

Chemical Name: 1-Hexadecyl-2-methyl-3-(phenylmethyl)-1H-imidazolium iodide

Product Details
Citations (4)
Reviews

Biological Activity

Eukaryotic elongation factor 2 (eEF-2) kinase (CaMK III) inhibitor (IC50 = 60 nM) that displays 125-fold, > 1300-fold and > 1500-fold selectivity over PKC, PKA and CaMK II respectively. Decreases the viability of a variety of cancer cell lines (IC50 values are 0.7 - 4.8 μM) and blocks G1/S cell cycle progression. Shown to induce eEF-2 phosphorylation in cancer cells. Also an effective antibacterial agent; inhibits histidine protein kinase in vitro (IC50 = 6.6 μM) and in vivo.

Technical Data

M.Wt:
524.56
Formula:
C27H45IN2
Solubility:
Soluble to 100 mM in DMSO and to 75 mM in ethanol
Storage:
Desiccate at -20°C
CAS No:
278603-08-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for NH 125

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4 Citations: Showing 1 - 4

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