Chemical Name: 1-Hexadecyl-2-methyl-3-(phenylmethyl)-1H-imidazolium iodide
Biological ActivityNH 125 is an eukaryotic elongation factor 2 (eEF-2) kinase (CaMK III) inhibitor (IC50 = 60 nM) that displays 125-fold, > 1300-fold and > 1500-fold selectivity over PKC, PKA and CaMK II respectively. Decreases the viability of a variety of cancer cell lines (IC50 values are 0.7 - 4.8 μM) and blocks G1/S cell cycle progression. Shown to induce eEF-2 phosphorylation in cancer cells. Also an effective antibacterial agent; inhibits histidine protein kinase in vitro (IC50 = 6.6 μM) and in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) induces phosphorylation of eukaryotic elongation factor-2 (eEF2): a cautionary note on the anticancer mechanism of an eEF2 kinase inhibitor.
Antibacterial agents that inhibit histidine protein kinase YycG of Bacillus subtilis.
Yamamoto et al.
Identification and characterization of an inhibitor of eukaryotic elongation factor 2 kinase against human cancer cell lines.
Arora et al.
Cancer Res., 2003;63:6894
P-glycoprotein mediates resistance to histidine kinase inhibitors.
Arora et al.
Citations for NH 125
The citations listed below are publications that use Tocris products. Selected citations for NH 125 include:
4 Citations: Showing 1 - 4
Neurons secrete miR-132-containing exosomes to regulate brain vascular integrity.
Authors: Xu Et al.
Cell Res 2017;27:882
Identification of an Antimicrobial Agent Effective against Methicillin-Resistant Staphylococcus aureus Persisters Using a Fluorescence-Based Screening Strategy.
Authors: Kim Et al.
PLoS One 2015;10:e0127640
Integrated regulation of autophagy and apoptosis by EEF2K controls cellular fate and modulates the efficacy of curcumin and vel. against tumor cells.
Authors: Cheng Et al.
Mechanistic insight into inhibition of two-component system signaling.
Authors: Francis Et al.
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