Chemical Name: Methyl 1-hydroxy-6-phenyl-4-(trifluoromethyl)-1H-indole-2-carboxylate
Biological ActivityNHI 2 is an LDHA inhibitor; reduces lactate production in HeLa cells. Inhibits cell growth of LPC006 and PANC-1 cells in vitro. Enhances the antiproliferative effects of Gemcitabine (Cat. No. 3259) on LPC006 and PANC-1 cells. Also inhibits ferroptosis.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
APD-containing cyclolipodepsipeptides target mitochondrial function in hypoxic cancer cells.
Jacobsen et al.
Cell Chem.Biol., 2018;25:1337
Dual targeting of the Warburg effect with a glucose-conjugated lactate dehydrogenase inhibitor.
Calvaresi et al.
Assessing the differential action on cancer cells of LDH-A inhibitors based on the N-hydroxyindole-2-carboxylate (NHI) and malonic (Mal) scaffolds.
Granchi et al.
Synergistic interaction of novel lactate dehydrogenase inhibitors with gemcit. against pancreatic cancer cells in hypoxia.
Maftouh et al.
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for NHI 2
There are currently no reviews for this product. Be the first to review NHI 2 and earn rewards!
Have you used NHI 2?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image