Chemical Name: Methyl 1-hydroxy-6-phenyl-4-(trifluoromethyl)-1H-indole-2-carboxylate
Biological ActivityLDHA inhibitor; reduces lactate production in HeLa cells. Inhibits cell growth of LPC006 and PANC-1 cells in vitro. Enhances the antiproliferative effects of Gemcitabine (Cat. No. 3259) on LPC006 and PANC-1 cells. Also inhibits ferroptosis.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
APD-containing cyclolipodepsipeptides target mitochondrial function in hypoxic cancer cells.
Jacobsen et al.
Cell Chem.Biol., 2018;25:1337
Dual targeting of the Warburg effect with a glucose-conjugated lactate dehydrogenase inhibitor.
Calvaresi et al.
Assessing the differential action on cancer cells of LDH-A inhibitors based on the N-hydroxyindole-2-carboxylate (NHI) and malonic (Mal) scaffolds.
Granchi et al.
Synergistic interaction of novel lactate dehydrogenase inhibitors with gemcit. against pancreatic cancer cells in hypoxia.
Maftouh et al.
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