Q: I'm looking for a Niemann-Pick type1 or 2 antibody to stain mouse heart section embedded in paraffin. I would like to label these sections with another primary antibody to show colocalisation of my protein of interest. I would like to know if you have a rabbit anti-Niemann-Pick antibody that works well for fluorescence immunohistochemistry?

A: Niemann-Pick C1 Antibody (NB400-148) (0.1 ml) is one of our best sellers and this antibody has been cited in at least 17 peer reviewed research publications in journals of high repute. We have only one Niemann-Pick type C2 antibody with catalog # H00010577-D01PInnovators Reward Program.

Niemann-Pick type C2 Antibody

Novus Biologicals | Catalog # NBP1-52028

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Product Documents

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Product Specifications
Scientific Data
Applications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Species Reactivity

Human

Applications

Western Blot, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

View all Niemann-Pick Type C2/NPC2 Primary Antibodies »

Product Specifications

Immunogen

Peptide with sequence QAEPVQFKDCGSVD corresponding to internal region according to NP_006423.1.

Epitope

QAEPVQFKDCGSVD

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for Niemann-Pick type C2 Antibody

Western Blot: Niemann-Pick type C2 Antibody [NBP1-52028]

Western Blot: Niemann-Pick type C2 Antibody [NBP1-52028] - Western blot analysis of Niemann-Pick type C2 in Human Testis lysate (35ug protein in RIPA buffer) using NBP1-52028 at 0.5ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence.

Applications for Niemann-Pick type C2 Antibody

Application

Recommended Usage

Peptide ELISA

Detection limit 1:2000

Western Blot

0.3 - 1 ug/ml

Application Notes

WB: Experiments gave bands at approx. 20 kDa band and 23 kDa band in human testis lysates. These bands correspond to earlier findings are reported in scientific literature with different antibodies (PMID: 16772431). This protein has a calculated MW of 16.6 kDa band according to NP_006423.1.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Niemann-Pick Type C2/NPC2

This gene encodes a protein containing a lipid recognition domain. The encoded protein may function in regulating the transport of cholesterol through the late endosomal/lysosomal system. Mutations in this gene have been associated with Niemann-Pick disease, type C2 and frontal lobe atrophy. [provided by RefSeq]

Alternate Names

EDDM1, Epididymal Protein 1, HE1, NiemannPick Type C2, NPC2

Entrez Gene IDs

10577 (Human)

Gene Symbol

NPC2

UniProt

NP_006423.1 (Human)

Additional Niemann-Pick Type C2/NPC2 Products

Product Documents for Niemann-Pick type C2 Antibody

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Certificate of Analysis

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Product Specific Notices for Niemann-Pick type C2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations for Niemann-Pick type C2 Antibody

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