Catalog Number: 0600
Chemical Name: 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methyloxyethyl 1-methylethyl ester
Biological Activity
L-type Ca2+ channel blocker.
Technical Data
  • M.Wt:
    418.45
  • Formula:
    C21H26N2O7
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    66085-59-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Effects of chronic nimodipine on working memory of old rats in relation to defects in synaptosomal calcium homeostasis.
    Batuecas et al.
    Eur.J.Pharmacol., 1998;350:141
  2. Nimodipine and the recovery of memory.
    Izquierdo
    TiPS, 1990;11:309
  3. Beneficial effect of the Ca2+ antagonist, nimodipine, on existing diabetic neuropathy in the BB/Wor rat.
    Kappelle et al.
    Br.J.Pharmacol., 1994;111:887
  4. Chemical modulators of autophagy as biological probes and potential therapeutics.
    Fleming et al.
    Nat.Chem.Biol., 2011;7:9
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Nimodipine include:

17 Citations: Showing 1 - 10
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  1. Swelling-activated Ca2+ channels trigger Ca2+ signals in Merkel cells.
    Authors: Haeberle Et al.
    Mol Biol Cell ;3:e1750
  2. Molecular basis of ancestral vertebrate electroreception.
    Authors: Bellono
    Nature 2017;543:391
  3. Tissue plasminogen activator inhibits NMDA-receptor-mediated increases in calcium levels in cultured hippocampal neurons.
    Authors: Robinson Et al.
    EMBO J 2015;9:404
  4. Wnt signalling tunes neurotransmitter release by directly targeting Synaptotagmin-1.
    Authors: Ciani Et al.
    PLoS One 2015;6:8302
  5. Absence of plateau potentials in dLGN cells leads to a breakdown in retinogeniculate refinement.
    Authors: Dilger Et al.
    J Neurosci 2015;35:3652
  6. Dendritic and axonal mechanisms of Ca2+ elevation impair BDNF transport in Aβ oligomer-treated hippocampal neurons.
    Authors: Gan and Silverman
    PLoS One 2015;26:1058
  7. Preventing effect of L-type calcium channel blockade on electrophysiological alterations in dentate gyrus granule cells induced by entorhinal amyloid pathology.
    Authors: Pourbadie Et al.
    Front Cell Neurosci 2015;10:e0117555
  8. An essential role for inhibitor-2 regulation of protein phosphatase-1 in synaptic scaling.
    Authors: Siddoway Et al.
    Br J Pharmacol 2013;33:11206
  9. Optogenetic stimulation of the corticothalamic pathway affects relay cells and GABAergic neurons differently in the mouse visual thalamus.
    Authors: Jurgens Et al.
    PLoS One 2012;7:e45717
  10. The loop diuretic bumetanide blocks posttraumatic p75NTR upregulation and rescues injured neurons.
    Authors: Shulga Et al.
    J Neurosci 2012;32:1757
  11. Action potential-independent and pharmacologically unique vesicular serotonin release from dendrites.
    Authors: Colgan Et al.
    J Neurosci 2012;32:15737
  12. Activity-dependent phosphorylation of GABAA receptors regulates receptor insertion and tonic current.
    Authors: Saliba Et al.
    J Neurosci 2012;31:2937
  13. Requirements for synaptically evoked plateau potentials in relay cells of the dorsal lateral geniculate nucleus of the mouse.
    Authors: Dilger Et al.
    J Physiol 2011;589:919
  14. Recovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT2C receptors.
    Authors: Murray Et al.
    Nat Med 2010;16:694
  15. Competitive regulation of synaptic Ca2+ influx by D2 dopamine and A2A adenosine receptors.
    Authors: Higley and Sabatini
    Nat Neurosci 2010;13:958
  16. Two coincidence detectors for spike timing-dependent plasticity in somatosensory cortex.
    Authors: Bender Et al.
    J Neurosci 2006;26:4166
  17. Molecular profiling reveals synaptic release machinery in Merkel cells.
    Authors: Haeberle Et al.
    Proc Natl Acad Sci U S A 2004;101:14503
Expand to show all 17 Citations

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