Chemical Name: (±)-γ-(2-Methoxyphenoxy)-N-methylbenzenepropanamine hydrochloride
Biological ActivityNisoxetine hydrochloride is a potent and selective inhibitor of noradrenalin uptake with little or no affinity for a range of other neurotransmitter receptors.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
[3H]Nisoxetine - a radioligand for noradrenaline reuptake sites: correlation with inhibition of [3H]noradrenaline uptake and effect of DSP-4 lesioning and antidepressant treatments.
Cheetham et al.
NE transporters in rat placenta labeled with [3H]nisoxetine.
Shearman and Meyer
Down-regulation of NE transporters on PC12 cells by transporter inhibitors.
Zhu et al.
dl-N-Methyl-3-(o-methoxyphenoxy)-3-phenylpropylamine hydrochloride, Lilly 94939, a potent inhibitor for uptake of NE into rat brain synaptosomes and heart.
Wong et al.
Life Sci., 1975;17:755
Citations for Nisoxetine hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Nisoxetine hydrochloride include:
5 Citations: Showing 1 - 5
Transient Receptor Potential Vanilloid 1 Modulates Central Inflammation in Multiple Sclerosis.
Authors: Bassi Et al.
Front Neurol 2019;10:30
Fluoxetine blocks Nav1.5 channels via a mechanism similar to that of class 1 antiarrhythmics.
Authors: Poulin Et al.
Mol Pharmacol 2014;86:378
Discovery of novel-scaffold monoamine transporter ligands via in silico screening with the S1 pocket of the serotonin transporter.
Authors: Nolan Et al.
ACS Chem Neurosci 2014;5:784
Amphetamine modulation of long-term potentiation in the prefrontal cortex: dose dependency, monoaminergic contributions, and paradoxical rescue in hyperDArgic mutant.
Authors: Xu Et al.
J Neurosci 2010;115:1643
Activation of glycogen synthase kinase-3 β is required for hyperDA and D2 receptor-mediated inhibition of synaptic NMDA receptor function in the rat prefrontal cortex.
Authors: Li Et al.
Front Cell Neurosci 2009;29:15551
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