NLRP11 Antibody

Novus Biologicals | Catalog # NBP2-24688

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Bovine (100%), Chimpanzee (100%), Mouse (100%), Rat (100%), Zebrafish (90%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG
View all NLRP11 Primary Antibodies »

Product Specifications

Immunogen

A portion of amino acids 850-900 of human NALP11 was used as the immunogen.

Reactivity Notes

The amino acid sequence used as immunogen is 84% homologous in Chicken.

Specificity

This antibody will detect the approximately 300 kD full-length Notch1form and the approximately 100 kD cleaved Notch1 form of the protein.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for NLRP11 Antibody

Immunohistochemistry-Paraffin: NLRP11 Antibody [NBP2-24688]

Immunohistochemistry-Paraffin: NLRP11 Antibody [NBP2-24688]

Immunohistochemistry-Paraffin: NLRP11 Antibody [NBP2-24688] - Analysis of NALP11. Formalin-fixed, paraffin-embedded human liver tissue probed with an isotype control antibody (top) and NALP11 antibody (bottom) at 5 ug/ml.

Applications for NLRP11 Antibody

Application
Recommended Usage

Immunohistochemistry-Paraffin

5 ug/ml

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS and 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: NLRP11

NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP11, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM]

Alternate Names

CLR19.6, NACHT, leucine rich repeat and PYD containing 11, NALP11NACHT, LRR and PYD domains-containing protein 11, NLR family, pyrin domain containing 11, NOD17PYPAF7, Nucleotide-binding oligomerization domain protein 17, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domaincontaining 11, PAAD- and NACHT-containing protein 10, PAAD- and NACHT-containing protein 10B, PAAD-and NACHT domain-containing protein 10, PAN10FLJ26273, PYPAF6NACHT, LRR and PYD containing protein 11, PYRIN-containing APAF1-like protein 6

Gene Symbol

NLRP11

UniProt

P59045 (Human)

Additional NLRP11 Products

Product Documents for NLRP11 Antibody

Certificate of Analysis

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Product Specific Notices for NLRP11 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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