Non-Human Primate BDNF Cartridge
R&D Systems | Catalog # SPCKB-NP-011279
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Key Product Details
Assay Length
Sample Type & Volume Required Per Well*
Sensitivity
Assay Range
Non-Human Primate BDNF Cartridge Summary
*The Sample Volume represented is based on the amount of sample incorporated into the reaction after taking into account the assay's minimum required dilution for a given matrix. Serial dilution may be necessary to achieve some of the final sample volumes represented.
Compatible Instruments
Ella Automated Immunoassay System
Product Specifications
Assay Type
Format
Species
Specificity
Cross-reactivity
Interference
Precision
Intra-Assay Precision (Precision within an assay) Each control was tested 16 times in one assay.
Inter-Assay Precision (Precision between assays) Replicates of each control were tested in multiple assays performed by at least three technicians using two lots of reagents.
Cell Culture Supernates, Platelet-poor Plasma, Serum
| Intra-Assay Precision | Inter-Assay Precision | |||
|---|---|---|---|---|
| Sample | 1 | 2 | 1 | 2 |
| n | 16 | 16 | 20 | 22 |
| Mean (pg/mL) | 207 | 10079 | 219 | 11200 |
| Standard Deviation | 19.8 | 867 | 22.9 | 1144 |
| CV% | 9.6 | 8.6 | 10.5 | 10.2 |
Recovery for Non-Human Primate BDNF Cartridge
Recovery at three different spiked concentrations within the range of the assay was evaluated.
| Sample Type | Average % Recovery | Range % |
|---|---|---|
| Cell Culture Supernates (n=2) | 97 | 94-101 |
Linearity
Samples containing and/or spiked with high concentrations of BDNF were serially diluted with Sample Diluent to produce samples within the dynamic range of the assay.
Scientific Data Images for Non-Human Primate BDNF Cartridge
Non-Human Primate BDNF Ella Assay Standard Curve
Preparation and Storage
Shipping
Stability & Storage
Background: BDNF
BDNF (Brain-Derived Neurotrophic Factor) is a secreted protein that regulates many aspects of neuronal development and function in the nervous system. It is produced as proBDNF in response to neuronal activity or inflammatory stimulation and is then cleaved before associating into a homodimer. It is expressed throughout the nervous system as well as by fibroblasts, megakaryocytes/platelets, and smooth muscle cells. BDNF regulates neural stem cell survival and differentiation, axon/dendrite differentiation, synapse formation and maturation, and refinement of developing circuits. It is also a key regulator of synaptic plasticity and late-phase long-term potentiation. BDNF signals through the TrkB and NGF R/TNFRSF16 receptors. Secreted proBDNF can bind to NGF R/TNFRSF16 and induce long-term depression and cell apoptosis.
Long Name
Alternate Names
Gene Symbol
Additional BDNF Products
Product Documents for Non-Human Primate BDNF Cartridge
Certificate of Analysis
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Product Specific Notices for Non-Human Primate BDNF Cartridge
For research use only
Related Research Areas
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