Non-Human Primate CCL4/MIP-1b Cartridge
R&D Systems | Catalog # SPCKB-NP-011340
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Key Product Details
Assay Length
Sample Type & Volume Required Per Well*
Sensitivity
Assay Range
Non-Human Primate CCL4/MIP-1b Cartridge Summary
*The Sample Volume represented is based on the amount of sample incorporated into the reaction after taking into account the assay's minimum required dilution for a given matrix. Serial dilution may be necessary to achieve some of the final sample volumes represented.
Compatible Instruments
Ella Automated Immunoassay System
Product Specifications
Assay Type
Format
Species
Specificity
Cross-reactivity
Interference
Precision
Intra-Assay Precision (Precision within an assay) Each control was tested 16 times in one assay.
Inter-Assay Precision (Precision between assays) Replicates of each control were tested in multiple assays performed by at least three technicians using two lots of reagents.
Cell Culture Supernates, EDTA Plasma, Heparin Plasma, Serum
| Intra-Assay Precision | Inter-Assay Precision | |||
|---|---|---|---|---|
| Sample | 1 | 2 | 1 | 2 |
| n | 16 | 16 | 102 | 99 |
| Mean (pg/mL) | 16.6 | 863 | 16.7 | 915 |
| Standard Deviation | 0.632 | 32.9 | 1.04 | 37.2 |
| CV% | 3.8 | 3.8 | 6.3 | 4.1 |
Recovery for Non-Human Primate CCL4/MIP-1b Cartridge
Recovery at three different spiked concentrations within the range of the assay was evaluated.
| Sample Type | Average % Recovery | Range % |
|---|---|---|
| Cell Culture Supernates (n=4) | 111 | 106-115 |
| EDTA Plasma (n=4) | 94 | 79-108 |
| Heparin Plasma (n=4) | 108 | 86-122 |
| Serum (n=6) | 108 | 94-122 |
Linearity
Samples containing and/or spiked with high concentrations of MIP-1 beta were serially diluted with Sample Diluent to produce samples within the dynamic range of the assay.
Scientific Data Images for Non-Human Primate CCL4/MIP-1b Cartridge
Non-Human Primate CCL4/MIP-1b Ella Assay Standard Curve
Preparation and Storage
Shipping
Stability & Storage
Background: CCL4/MIP-1 beta
CCL4/MIP-1 beta is a beta chemokine that is secreted at sites of inflammation by activated leukocytes, lymphocytes, vascular endothelial cells, and pulmonary smooth muscle cells. It attracts a variety of immune cells to sites of microbial infection as well as to other pathologic inflammation such as allergic asthma and ischemic myocardium. CCL4 is secreted from activated monocytes as a heterodimer with CCL3/MIP-1 alpha. It signals through CCR5, and an N-terminally trimmed form additionally interacts with CCR1 and CCR2. In humans, the ability of CCL4 to bind CCR5 inhibits the cellular entry of M-tropic HIV-1 which utilizes CCR5 as a coreceptor.
Alternate Names
Entrez Gene IDs
Gene Symbol
Additional CCL4/MIP-1 beta Products
Product Documents for Non-Human Primate CCL4/MIP-1b Cartridge
Certificate of Analysis
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Product Specific Notices for Non-Human Primate CCL4/MIP-1b Cartridge
For research use only
Citations for Non-Human Primate CCL4/MIP-1b Cartridge
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