NU 9056

Catalog # Availability Size / Price Qty
4903/10
Cat.No. 4903 - NU 9056 | C6H4N2S4 | CAS No. 1450644-28-6
1 Image
Description: Inhibitor of KAT5 (Tip60)

Chemical Name: 5-(1,2-Thiazol-5-yldisulfanyl)-1,2-thiazole

Product Details
Citations (3)
Reviews

Biological Activity

Selective KAT5 (Tip60) histone acetyltransferase inhibitor (IC50 values are < 2, 60, 36, and >100 μM for KAT5, p300, pCAF and GCN5, respectively). Inhibits protein acetylation in prostate cancer cell lines and blocks DNA damage response. Decreases proliferation of LNCaP cells; induces apoptosis via caspase activation.

Technical Data

M.Wt:
232.37
Formula:
C6H4N2S4
Solubility:
Soluble in DMSO (supplied pre-dissolved in DMSO, 10mg/ml)
Storage:
Store at -20°C
CAS No:
1450644-28-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer.
    Coffey et al.
    PLoS One, 2012;7:e45539

Product Datasheets

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Citations for NU 9056

The citations listed below are publications that use Tocris products. Selected citations for NU 9056 include:

3 Citations: Showing 1 - 3

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