Chemical Name: 5-(1,2-Thiazol-5-yldisulfanyl)-1,2-thiazole
Biological ActivitySelective KAT5 (Tip60) histone acetyltransferase inhibitor (IC50 values are < 2, 60, 36, and >100 μM for KAT5, p300, pCAF and GCN5, respectively). Inhibits protein acetylation in prostate cancer cell lines and blocks DNA damage response. Decreases proliferation of LNCaP cells; induces apoptosis via caspase activation.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer.
Coffey et al.
PLoS One, 2012;7:e45539
Citations for NU 9056
The citations listed below are publications that use Tocris products. Selected citations for NU 9056 include:
3 Citations: Showing 1 - 3
Novel complex of HAT protein TIP60 and nuclear receptor PXR promotes cell migration and adhesion.
Authors: Bakshi Et al.
Sci Rep 2017;7:3635
Novel detection of post-translational modifications in human monocyte-derived dendritic cells after chronic alcohol exposure: Role of inflammation regulator H4K12ac.
Authors: Parira Et al.
Sci Rep 2017;7:11236
Lysine acetyltransferase NuA4 and acetyl-CoA regulate glucose-deprived stress granule formation in Saccharomyces cerevisiae.
Authors: Rollins Et al.
PLoS Genet 2017;13:e1006626
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