Chemical Name: 5-(1,2-Thiazol-5-yldisulfanyl)-1,2-thiazole
Biological ActivitySelective KAT5 (Tip60) histone acetyltransferase inhibitor (IC50 values are < 2, 60, 36, and >100 μM for KAT5, p300, pCAF and GCN5, respectively). Inhibits protein acetylation in prostate cancer cell lines and blocks DNA damage response. Decreases proliferation of LNCaP cells; induces apoptosis via caspase activation.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer.
Coffey et al.
PLoS One, 2012;7:e45539
Citations for NU 9056
The citations listed below are publications that use Tocris products. Selected citations for NU 9056 include:
6 Citations: Showing 1 - 6
PRMT5-mediated regulation of developmental myelination.
Authors: Scaglione Et al.
Nat Commun 2018;9:2840
Blocking H2A.Z Incorporation via Tip60 Inhibition Promotes Systems Consolidation of Fear Memory in Mice.
Authors: Narkaj Et al.
Expression of DHA-Metabolizing Enzyme Alox15 is Regulated by Selective Histone Acetylation in Neuroblastoma Cells.
Authors: Ho Et al.
Neurochem Res 2018;43:540
Novel complex of HAT protein TIP60 and nuclear receptor PXR promotes cell migration and adhesion.
Authors: Bakshi Et al.
Sci Rep 2017;7:3635
Novel detection of post-translational modifications in human monocyte-derived dendritic cells after chronic alcohol exposure: Role of inflammation regulator H4K12ac.
Authors: Parira Et al.
Sci Rep 2017;7:11236
Lysine acetyltransferase NuA4 and acetyl-CoA regulate glucose-deprived stress granule formation in Saccharomyces cerevisiae.
Authors: Rollins Et al.
PLoS Genet 2017;13:e1006626
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