Home / Histone Acetyltransferase Inhibitors / NU 9056

NU 9056

Catalog #: 4903
6 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4903/10
NU 9056 | CAS No. 1450644-28-6 | Histone Acetyltransferase Inhibitors
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Description: Inhibitor of KAT5 (Tip60)

Chemical Name: 5-(1,2-Thiazol-5-yldisulfanyl)-1,2-thiazole

Product Details
Citations (6)
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Biological Activity

NU 9056 is a selective KAT5 (Tip60) histone acetyltransferase inhibitor (IC50 values are < 2, 60, 36, and >100 μM for KAT5, p300, pCAF and GCN5, respectively). Inhibits protein acetylation in prostate cancer cell lines and blocks DNA damage response. Decreases proliferation of LNCaP cells; induces apoptosis via caspase activation.

Technical Data

M.Wt:
232.37
Formula:
C6H4N2S4
Solubility:
Soluble in DMSO (supplied pre-dissolved in DMSO, 10mg/ml)
Storage:
Store at -20°C
CAS No:
1450644-28-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer.
    Coffey et al.
    PLoS One, 2012;7:e45539

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Citations for NU 9056

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