Selective KAT5 (Tip60) histone acetyltransferase inhibitor (IC50
values are < 2, 60, 36, and >100 μ
M for KAT5, p300, pCAF and GCN5, respectively). Inhibits protein acetylation in prostate cancer cell lines and blocks DNA damage response. Decreases proliferation of LNCaP cells; induces apoptosis via caspase activation.
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All Tocris products are intended for laboratory research use only.
Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer.
Coffey et al.
PLoS One, 2012;7:e45539