Catalog Number: 4903
Chemical Name: 5-(1,2-Thiazol-5-yldisulfanyl)-1,2-thiazole
Biological Activity
Selective KAT5 (Tip60) histone acetyltransferase inhibitor (IC50 values are < 2, 60, 36, and >100 μM for KAT5, p300, pCAF and GCN5, respectively). Inhibits protein acetylation in prostate cancer cell lines and blocks DNA damage response. Decreases proliferation of LNCaP cells; induces apoptosis via caspase activation.
Technical Data
  • M.Wt:
    232.37
  • Formula:
    C6H4N2S4
  • Solubility:
    Soluble in DMSO (supplied pre-dissolved in DMSO, 10mg/ml)
  • Storage:
    Store at -20°C
  • CAS No:
    1450644-28-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer.
    Coffey et al.
    PLoS One, 2012;7:e45539

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