Biological ActivityHighly potent integrin α1β1 inhibitor (IC50 = 0.8 nM for α1β1 binding to type IV collagen). Selective for α1β1 over α2β1, αIIbβ3, αvβ3, α4β1, α5β6, α9β1 and α4β7. Inhibits FGF2-stimulated angiogenesis in the chicken chorioallantoic model. Displays antitumor efficacy in a synergistic mouse model of Lewis lung carcinoma; blocks human melanoma growth in nude mice.
(Modifications: Disulfide bridge: 1 - 10, 6 - 29, 7 - 34, 19 - 36)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Amino acid sequence and homology modeling of obtustatin, a novel non-RGD-containing short disintegrin isolated from the venom of Vipera lebetina obtusa.
Moreno-Murciano et al.
Protein Sci., 2003;12:366
Obtustatin: a potent and selective inhibitor of α1β1 integrin in vitro and angiogenesis in vivo.
Marcinkiewicz et al.
Cancer Res., 2003;63:2020
Angiostatic activity of obtustatin as α1β1 integrin inhibitor in experimental melanoma growth.
Brown et al.
Citations for Obtustatin
The citations listed below are publications that use Tocris products. Selected citations for Obtustatin include:
2 Citations: Showing 1 - 2
Collagen Type 1 accelerates healing of ruptured fetal membranes.
Sci Rep 2018;8(1):696
Reciprocal signalling by Notch-Collagen V-CALCR retains muscle stem cells in their niche
No product specific FAQs exist for this product, however you mayView all Peptide FAQs
VersaClone cDNA Plasmids
Reviews for Obtustatin
There are currently no reviews for this product. Be the first to review Obtustatin and earn rewards!
Have you used Obtustatin?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image