Highly potent integrin α1β1
= 0.8 nM for α1β1
binding to type IV collagen). Selective for α1β1
. Inhibits FGF2-stimulated angiogenesis in the chicken chorioallantoic model. Displays antitumor efficacy in a synergistic mouse model of Lewis lung carcinoma; blocks human melanoma growth in nude mice.
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All Tocris products are intended for laboratory research use only.
Obtustatin: a potent and selective inhibitor of α1β1 integrin in vitro and angiogenesis in vivo.
Marcinkiewicz et al.
Cancer Res., 2003;63:2020
Amino acid sequence and homology modeling of obtustatin, a novel non-RGD-containing short disintegrin isolated from the venom of Vipera lebetina obtusa.
Moreno-Murciano et al.
Protein Sci., 2003;12:366
Angiostatic activity of obtustatin as α1β1 integrin inhibitor in experimental melanoma growth.
Brown et al.