Biological ActivityHighly potent integrin α1β1 inhibitor (IC50 = 0.8 nM for α1β1 binding to type IV collagen). Selective for α1β1 over α2β1, αIIbβ3, αvβ3, α4β1, α5β6, α9β1 and α4β7. Inhibits FGF2-stimulated angiogenesis in the chicken chorioallantoic model. Displays antitumor efficacy in a synergistic mouse model of Lewis lung carcinoma; blocks human melanoma growth in nude mice.
(Modifications: Disulfide bridge: 1 - 10, 6 - 29, 7 - 34, 19 - 36)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Obtustatin: a potent and selective inhibitor of α1β1 integrin in vitro and angiogenesis in vivo.
Marcinkiewicz et al.
Cancer Res., 2003;63:2020
Angiostatic activity of obtustatin as α1β1 integrin inhibitor in experimental melanoma growth.
Brown et al.
Amino acid sequence and homology modeling of obtustatin, a novel non-RGD-containing short disintegrin isolated from the venom of Vipera lebetina obtusa.
Moreno-Murciano et al.
Protein Sci., 2003;12:366
Citations for Obtustatin
The citations listed below are publications that use Tocris products. Selected citations for Obtustatin include:
2 Citations: Showing 1 - 2
Collagen Type 1 accelerates healing of ruptured fetal membranes.
Sci Rep 2018;8(1):696
Reciprocal signalling by Notch-Collagen V-CALCR retains muscle stem cells in their niche
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10 μg/ml treat 24h and 48h