ONO AE3 208

Tocris Bioscience | Catalog # 3565

High affinity and selective EP4 antagonist
Tocris Bioscience

Key Product Details

Description

High affinity and selective EP4 antagonist
View all Prostanoid Receptor Antagonists »

Product Description

ONO AE3 208 is a high affinity and selective EP4 receptor antagonist (Ki values are 1.3, 30, 790 and 2400 nM for EP4, EP3, FP and TP receptors respectively). Displays no affinity for EP1, EP2, DP or IP receptors (Ki >10 μM). Inhibits PGE2-induced IL-8 production in colonic epithelial caco-2 cells and attenuates PGE2 inhibition of natural killer T cell activation. Suppresses recovery from experimentally-induced colitis and stimulates CD4+ T cell proliferation in C57BL/6 mice. Also reduces metastasis of mammary tumor cells in a murine model of breast cancer. Orally active.

Product Specifications for ONO AE3 208

Molecular Weight

404.43

Formula

C24H21FN2O3

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

4-Cyano-2-[[2-(4-fluoro-1-naphthalenyl)-1-oxopropyl]amino]benzenebutanoic acid

CAS Number

402473-54-5

PubChem ID

10111831

InChI Key

MTDIMKNAJUQTIO-UHFFFAOYSA-N

SMILES

O=C(C(C)C2=C(C=CC=C3)C3=C(F)C=C2)NC1=CC(C#N)=CC=C1CCCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.44 100

Preparing Stock Solutions for ONO AE3 208

The following data is based on the product molecular weight 404.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.47 mL 12.36 mL 24.73 mL
5 mM 0.49 mL 2.47 mL 4.95 mL
10 mM 0.25 mL 1.24 mL 2.47 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 15 publications citing the usage of this product.

Product Documents for ONO AE3 208

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for ONO AE3 208

For research use only

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  • ONO AE3 208
    Name: Melanie Ikeh
    Verified Customer | Posted 05/31/2017
    in vivo survival assay

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