Catalog Number: 3565
Chemical Name: 4-Cyano-2-[[2-(4-fluoro-1-naphthalenyl)-1-oxopropyl]amino]benzenebutanoic acid
Biological Activity
High affinity and selective EP4 receptor antagonist (Ki values are 1.3, 30, 790 and 2400 nM for EP4, EP3, FP and TP receptors respectively). Displays no affinity for EP1, EP2, DP or IP receptors (Ki >10 μM). Inhibits PGE2-induced IL-8 production in colonic epithelial caco-2 cells and attenuates PGE2 inhibition of natural killer T cell activation. Suppresses recovery from experimentally-induced colitis and stimulates CD4+ T cell proliferation in C57BL/6 mice. Also reduces metastasis of mammary tumor cells in a murine model of breast cancer. Orally active.
Technical Data
  • M.Wt:
    404.43
  • Formula:
    C24H21FN2O3
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in 1.1eq. NaOH with gentle warming
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    402473-54-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Exosome-like nanoparticles from intestinal mucosal cells carry prostaglandin E2 and suppress activation of liver NKT cells.
    Deng et al.
    J.Immunol., 2013;190:3579
  2. Prostaglandin E receptor EP4 antagonism inhibits breast cancer metastasis.
    Ma et al.
    Cancer Res., 2006;66:2923
  3. Prostaglandin E2 couples through EP4 prostanoid receptors to induce IL-8 production in human colonic epithelial cell lines.
    Dey et al.
    Br.J.Pharmacol, 2009;3:475
  4. The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut.
    Kabashima et al.
    J.Clin.Invest., 2002;109:883
Average Rating: 5 (Based on 1 review)

Have you used ONO AE3 208?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Read what people are saying who have used ONO AE3 208.

Filter by Ratings
Excellent
(1)
All Ratings
Filter by Applications
All Applications
Filter by Species
All Species

Images Ratings Applications Species Reviewed By Date Details
  Excellent
  Anonymous 05/31/2017
Show

Other Experimental Details

Other Experimental Detailsin vivo survival assay

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

or select another batch: 

Feedback

Customer Information