Key Product Details

Species Reactivity

Human

Applications

ELISA Standard (Matched Pair), ELISA Capture (Matched Antibody Pair), ELISA Detection (Matched Antibody Pair)

Label

PE (Excitation = 488 nm, Emission = 575 nm)

Antibody Source

Monoclonal Mouse IgG2A Clone # 69127
View all Osteoprotegerin/TNFRSF11B Primary Antibodies »

Product Specifications

Immunogen

S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Osteoprotegerin/TNFRSF11B
Glu22-Leu401
Accession # O00300

Specificity

Detects human Osteoprotegerin/TNFRSF11B in ELISAs. It has been reported (1), and R&D Systems testing has confirmed, that this antibody shows strong cross-reactivity with an unrelated protein, human Carbonic Anhydrase II. In Western blots, this antibody does not cross‑react with recombinant human (rh) 4‑1BB, rhCD27, rhCD30, recombinant mouse (rm) CD30, rmCD40, rhDR3, rhDR6, rhFas, rmFas, rhGITR, rmGITR, rhHVEM, rhLT beta R, rhNGF R, rmOPG, rhTNF RI, rmTNF RI, rhTNF RII, or rmTNF RII.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Applications for Osteoprotegerin/TNFRSF11B Antibody (69127) [PE]

Application
Recommended Usage

ELISA Capture (Matched Antibody Pair)

Optimal dilutions of this antibody should be experimentally determined.

ELISA Detection (Matched Antibody Pair)

Optimal dilutions of this antibody should be experimentally determined.

ELISA Standard (Matched Pair)

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified from ascites

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: Osteoprotegerin/TNFRSF11B

Osteoprotegerin is encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq]

Alternate Names

OCIF, TNFRSF11B

Gene Symbol

TNFRSF11B

Additional Osteoprotegerin/TNFRSF11B Products

Product Documents for Osteoprotegerin/TNFRSF11B Antibody (69127) [PE]

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for Osteoprotegerin/TNFRSF11B Antibody (69127) [PE]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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FAQs

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