Catalog Number: 3864
Chemical Name: 10,11-Dihydro-10-oxo-5H-dibenzo(Z)[b,f]azepine-5-carboxamide
Biological Activity
Anticonvulsant; protects mice and rats against generalized tonic-clonic seizures induced by electroshock. Thought to act via inhibition of sodium channel activity.
Technical Data
  • M.Wt:
    252.27
  • Formula:
    C15H12N2O2
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    28721-07-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Oxcarbazepine: preclinical anticonvulsant profile and putative mechanism of action.
    Schmutz et al.
    Epilepsia, 1994;35:S47
  2. Oxcarbazepine, not its active metabolite, potentiates GABAA activation and aggravates absence seizures.
    Zheng et al.
    Epilepsia, 2009;50:83
  3. Mechanism of action of carbamazepine and its derivatives, oxcarbazepine, BIA 2-093, and BIA 2-024.
    Ambrosio et al.
    Neurochem.Res., 2002;27:121

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