Chemical Name: 10,11-Dihydro-10-hydroxy-5H-dibenz(Z)[b,f]azepin-5-carboxamide
Biological ActivityActive metabolite of oxcarbazepine (Cat. No. 3864). Produces dose-dependent inhibition of glutamatergic excitatory postsynaptic potentials (EPSPs). Displays anticonvulsant activity; exhibits minor potentiation of GABAA receptor currents.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Oxcarbazepine, not its active metabolite, potentiates GABAA activation and aggravates absence seizures.
Zheng et al.
Action of GP 47779, the active metabolite of oxcarbazepine, on the corticostriatal system. I. Modulation of corticostriatal synaptic transmission.
Calabresi et al.
Anticonvulsant and sodium channel-blocking properties of novel 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives.
Benes et al.
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Inhibiting currents through voltage gated sodium channel Nav1.5 in HEK-293-Nav1.5 cells. We used it at a concentration of 300 micromolar.